C4 Therapeutics, Inc.

Gesine Kerstin Veits

Christopher G Nasveschuk

Ning Yin

Andrew John Phillips

Yanke Liang

James A Henderson

Minsheng He

Kiel Lazarski

Katrina L Jackson

Rhamy Zeid

Moses Moustakim

Jeremy L Yap

Harit U Vora

Alexander W Hird

Chris G Nasveschuk

Andrew Charles Good

Hongwei Huang

Scott Joseph Eron

This invention provides Degron compounds which bind to cereblon which is a component of the E3 ubiquitin ligase. The Degrons provided herein can be used to modulate the activity of cereblon either alone or as covalently linked to a Tail. Alternatively, the Degron can be linked to a Targeting Ligand which binds to a Target Protein for protein degradation.

Bicyclic-substituted glutarimide cereblon binders

BRD9 protein degradation compounds or pharmaceutically acceptable salts thereof are provided for the treatment of disorders mediated by BRD9, including but not limited to abnormal cellular proliferation.

Compounds for targeted degradation of BRD9

This invention provides Degronimers that have carbon-linked E3 Ubiquitin Ligase targeting moieties (Degrons), which can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

C-carbon linked glutarimide degronimers for target protein degradation

The invention provides cereblon binders of Formulas: or pharmaceutically acceptable salts thereof, for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway along with their use in therapeutic applications to treat medical disorders including, but not limited to cancer.

Cereblon binders for the degradation of ikaros

A BRD9 protein degrading compound of structure or a pharmaceutically acceptable salt thereof is provided for the treatment of a disorder mediated by BRD9, including but not limited to abnormal cellular proliferation including cancer.

C3-carbon linked glutarimide degronimers for target protein degradation

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Watertown, MA, United States of America

Gesine Kerstin Veits