Medizinische Hochschule Hannover

Technische Universitát Dresden

Twincore, Zentrum Fur Experimentelle Und Klinische Infektionsforschung Gmbh

Gesine Hansen

Christian Hennig

Thomas Pietschmann

Sibylle Haid

Daniel Todt

Martin Wetzke

Chris Lauber

Lars Kaderali

The present invention pertains to a method for the identification of genetic variants that are associated with the severity of an infectious disease. The invention further pertains to a set of genetic factors associated with the severity of Human respiratory syncytial virus (HRSV) infection, for example in human infants. The genetic polymorphisms identified according to the present invention are for use in the diagnostic of infectious diseases and patient stratification in order to avoid or reduce the occurrence of fatal events during infection or to elect the most appropriate therapeutic approach to treat the disease.

Diagnostics and therapy for human respiratory syncytial virus

The invention provides a combination of reagents as a test kit containing a detection conjugate having a binding portion and a reagent for deactivating of the fluorochrome portion by interaction with the linker. The binding portion especially is an antibody portion. The detection conjugate has a fluorochrome portion connected to the antibody portion, and a linker connected to the fluorochrome portion, wherein the linker comprises an oligonucleotide. The fluorochrome portion can be deactivated by hydrolysis of the linker or by specific hybridization of a quencher having an oligonucleotide to the linker.

Detection conjugate and method for analysis

Growing community of inventors

Hannover, Germany

Gesine Hansen