The United States of America, as Represented by the Secretary, Department of Health and Human Services

Neodynamics Ab

The United States of America as Represented by the Department of Health

West Virginia University

Neoproteomics Ab

Vibratech Ab

Universität Zu Lübeck

Auer, Gert

Gert Auer

Hans Wiksell

Vilhelm Ekstrand

Thomas Ried

Jens Habermann

Nancy Lan Guo

Catharina Larsson

Kerstin Heselmeyer

Timo Gemoll

Evelin Schrock

Susanne Becker

Bo Franzèn

Kerstin Heselmeyer-Haddad

Merryn Macville

Karl Thomas Ried

Winfried Steinberg

Sonia Andersson

Marta Lomnytska

Peter Harge

Karl Thomas Reid

Uwe Johannes Roblick

Jens Karsten Habermann

The present embodiments relate generally to the field of cancer diagnostics. More specifically the embodiments relate to platelet derived biomarkers used for diagnosis of cancer or cancer progression, as well as prognosis and improved treatment.

Platelet biomarkers in cancer diagnosis

Methods of assessing genomic instability in breast cancer tissue by measuring the expression level of genes CDKN2A, SCYA18, STK15, NXF1, cDNA Dkfzp762M127, p28 KIAA0882, MYB, Human clone 23948, RERG, HNF3A, and ACADSB or a nucleic acid sequence comprising about 90% or greater sequence identity to SEQ ID NO: 21 in breast cancer tissue, an array suitable for use in such methods, and related methods and compositions.

Gene expression signature of genomic instability in breast cancer

The present invention relates to an anti-seeding arrangement () for invasive treatment of a human or animal body comprising an elongated hollow member (), and a first electrode () of which one portion is arranged near one end of the elongated hollow member (), said first electrode () being connectable to an electromagnetic field generator (), wherein the elongated hollow member () is arranged to be inserted into the human or animal body, control means () arranged to control the electromagnetic field generator () for delivering radio frequency bursts to the first electrode (), and sensing means () to sense a physical property dependent on the insertion length of the elongated hollow member () in the human or animal body, and wherein the control means () is arranged to control the operation of the electromagnetic field generator () in dependence of the sensed physical property.

Anti-seeding arrangement

The invention provides methods for identifying conditions of low grade cervical dysplasia and assessing the progressive potential of individual lesions to develop into high grade cervical dysplasia and cervical squamous cell cancer as well as cervical adenocarcinoma.

Method for detecting risk of progression of low grade cervical dysplasia

Fine needle arrangement for taking a sample of cells from suspicious lesions by using fine needle aspiration (FNA) technique, including a tubular needle member (), a storage compartment () enclosing a chamber, and a coupling () to which a connector may be attached. The chamber is configured with a gradually increasing cross-sectional area from the distal part of the chamber to the proximal part of the chamber, such that the chamber has no residual spaces where cell samples may be trapped, and that an efficient air streaming is achieved.

Fine needle arrangement for cell sampling

An arrangement for taking a sample of cells from a suspicious lesion or a tumor with the so called fine needle aspiration technique, provides a good penetration of tumors, especially small and/or hard fibrous tumors, and in the meantime yielding an increased amount of cells in the sample, by applying a longitudinal movement to the needle when the needle is penetrating the tumor and by applying both a rotational and a longitudinal movement to the needle when the needle is positioned inside the tumor. The arrangement is further provided with heat generating elements in order to apply a short pulse of heat to the needle in order to lower the risk for the tumor to spread.

Arrangement for cell sampling

The invention provides a method of detecting the presence of invasive cervical carcinoma in a subject comprising detecting in a cervical cell from the subject the presence of a chromosome abnormality which is associated with invasive cervical carcinoma; the presence of the cervical cell containing the chromosome abnormality indicating the presence of invasive cervical carcinoma in the subject. The invention also provides a method of detecting the presence of advanced-stage cervical carcinoma in a subject comprising detecting in a cervical cell from the subject the presence of a chromosome abnormality associated with advanced-stage cervical carcinoma; the presence of the cervical cell containing the chromosome abnormality indicating the presence of advanced-stage cervical carcinoma in the subject. The invention also provides a method of classifying the progression of dysplastic cervical cells from a non-invasive cervical carcinoma to an invasive cervical carcinoma comprising analyzing the dysplastic cervical cells for the presence of a chromosome abnormality which is associated with invasive cervical carcinoma, and classifying the dysplastic cervical cells having the chromosome abnormality as having progressed from a non-invasive cervical carcinoma cells to an invasive cervical carcinoma. The invention further provides kits comprising nucleic acids that specifically hybridize to chromosome 3q and specifically hybridize to another chromosome, and to compositions comprising nucleic acids.

Methods for detecting cervical cancer

Growing community of inventors

Solna, Sweden

Gert Auer