Duphar International Research Bv

Gerrit P Toorop

Gerben M Visser

Cornelis G Kruse

Gustaaf J M Van Scharrenburg

Roelof W Feenstra

Martinus T M Tulp

Jacobus A J Den Hartog

Johannes A M Van Der Heijden

Stephen K Long

Eric Ronken

Jacobus A Den Hartog

Johannes Mos

Josephus H Lange

Johannes W C M Jansen

Jan H Reinders

Ineke V Wijngaarden

The invention relates to a group of novel piperazine and piperidine derivatives of formula (I), wherein: S is hydrogen, halogen, alkyl (1-3C), CN, CF , OCF , SCF , alkoxy (1-3C), amino or mono- or dialkyl (1-3C) substituted amino, or hydroxy; X represents NR , S, CH , O, SO or SO , wherein R is H or alkyl (1-3C); . . . Z represents &boxH;C or &mdash;N; &mdash;R independently represent H or alkyl (1-3C), or R and R together can form a bridge 2 or 3 C-atoms; R is hydrogen or alkyl (1-3C); Q is methyl, ethyl, ethyl substituted with one or more fluorine atoms, cyclopropyl&mdash;methyl, optionally substituted with one or more fluorine atoms, and salts and prodrugs thereof. It has been found that these compounds have both partial dopamine D -receptor agonism and partial serotonin 5-HT -receptor agonism mediated activities.

Piperazine and piperidine compounds

The present invention relates to novel compounds, to a method for the preparation of these novel compounds, to pharmaceutical compositions containing one or more of these compounds as an active component and to methods of using these in the treatment of stress-related disorders.

Quinoline and quinazoline derivatives having corticotropin releasing factor (CRF) antagonist activity

The invention relates to compounds having anti-ischaemic activity, memory enhancing activity and anti-convulsive activity of the formulae 1A and 1B ##STR1## wherein R.sub.1 +R.sub.2 together form an alkylene group having 1-3 C-atoms which may be substituted with one or more alkyl group(s) having 1-3 C-atoms and the remaining R and Z variables are defined as disclosed herein, or a pharmacologically acceptable salt thereof.

Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory

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Weesp, Netherlands

Gerrit P Toorop