Synthon B.v.

Gerrit Jan Bouke Ettema

Jacobus Maria Lemmens

Frantisek Picha

Lambertus Thijs

Rolf Keltjens

Faysal Kalmoua

Korinde Annemarie Jansen

Theodorus Hendricus Antonius Peters

Farid Abedin Dorkoosh

Raymond Jozef Hubertus Westheim

Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent.

Process for making bicalutamide and intermediates thereof

Imidazopyridine compounds of the formula 1 are can be made in high purity, e.g. greater than 95% pure, by a process that use a novel intermediate of formula 5:

Imidazopyridine derivatives and process for making them

Zolpidem salts having improved physical stability do not exhibit a melting endotherm corresponding to zolpidem free base when heated at 5&deg; C./minute from about 25&deg; C. to 250&deg; C. The salts are generally easy to reproduce, even on an industrial scale and are easier to handle due to the increased stability than the known zolpidem tartrate. The zolpidem salts are typically pharmaceutically acceptable salts and can be used in formulating pharmaceutical compositions and in pharmaceutical uses; e.g. as a hypnotic.

Zolpidem salt forms

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Denekamp, Netherlands

Gerrit Jan Bouke Ettema