Schering Aktiengesellschaft

Gernot Langer

Martin Haberey

Gerald Kirsch

Andreas Steinmeyer

Katica Schwarz

Herbert Wiesinger

Werner Skuballa

Gunter Neef

William J Guilford

Bernd Buchmann

Bernard Jacques Haendler

Werner Boidol

Bernhard Lindenthal

Marianne Fahnrich

Daryl Faulds

G&uuml;nter Neef

Wolf-Dieter Schleuning

Vladimir Patchev

Luisella Toschi

Peter Donner

Alejandro Alagon

Berthold Baldus

Siegmund Wolf

Marianne F&auml;hnrich

Judy Li

Youriy Mitev

Jorn Reiner Kratzschmar

The present invention relates to 9-chloroprostaglandin derivatives of the general formula I which may be advantageous for the treatment of fertility problems. 

9-chloro-15-deoxyprostaglandin derivatives, process for their preparation and their use as medicaments

A method for in vitro screening a group of test substances for a ligand using two assay systems, i.e. a cellular or tissue assay system and an enzymatic assay system, is described. First, those test substances are selected which have transcriptional ER-mediated activity measured by an ER-driven reporter gene in the cellular or tissue assay system with an EC(half-maximally effective ligand concentration) lower than or equal to 10 nmol/l. Then in an enzymatic assay system the selected test substances having the required transcriptional ER-mediated activity are tested by measuring a physical-chemical interaction (recruitment) of SRC-1 and the ER in the presence of the test substances. The selected ligand activates the ER and induces interaction with the co-present SRC-1 with an Ehigher than or equal to 100 nmol/l. The ligands found by the inventive screening method are useful for treatment and prevention of neuro-degeneration in the cerebral cortex, especially of age-related cognitive disorders, affective disorders, Alzheimer's diseases and cerebral ischemia/stroke.

In Vitro screening for ligands of the estrogen receptor

The invention relates to novel vitamin D derivatives of general formula (I), a method for the production thereof, intermediate products of the method and the utilization of vitamin D derivatives for producing medicaments.

Vitamin D derivatives with cyclopropyl rings in the lateral chains, a method and intermediate products for the production thereof and the utilization thereof for producing medicaments

Described are new vitamin D derivatives such as of the formula (I) detailed in this disclosure. Also described are methods for preparing these derivatives, inter mediates used to prepare the derivatives and use of the derivatives as pharmaceutical agents.

Vitamin D derivatives with phosphorus atoms in the side chains

The present invention relates to novel thrombolitic v-PA's which dissolve blood clots in the human body and thus are suitable for the treatment of cardial infarction, for example.

Plasminogen activator from saliva of the vampire bat

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Berlin, Germany

Gernot Langer