Farmitalia Carlo Erba S.r.l.

Farmitalia Carlo Erba S.p.a.

Germano Carganico

Paolo Cozzi

Antonio Pillan

Patricia Salvati

Corrado Ferti

Umberto Branzoli

Dino Severino

Augusto Chiari

Mariia Menichincheri

Pierpaolo Lovisolo

Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dihydropyridines of formula (I) ##STR1## wherein Het is ##STR2## A represents a direct linkage, --CH.sub.2 --, CH.sub.2 --CH.sub.2 -- or, when Het is ##STR3## A may also represent --CH.dbd.CH--; R is hydrogen, halogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy; each of R.sub.3 and R.sub.4 is a C.sub.1 -C.sub.3 alkyl group; one of R.sub.1 and R.sub.2 is a group --OR' wherein R' is a C.sub.1 -C.sub.6 alkyl either unsubstituted or omega substituted by C.sub.1 -C.sub.3 alkoxy or cyano, and the other is, independently,

Imidazolyl and pyridyl derivatives of phenyl substituted

N-imidazolyl- and N-imidazolylmethyl-derivatives of substituted bicyclic

Hypolipidaemic imidazol-2-yl-derivatives of bicyclic compounds

A pharmaceutical compositon having activity against nephropathies comprising, as an active agent, a therapeutically effective amount of a compound of formula (I) ##STR1## wherein (a) ##STR2## wherein Y completes a single bond or is oxygen or a --CH.sub.2 -- group and the symbol ##STR3## represents a single bond or (b) ##STR4## ##STR5## and the symbol ##STR6## represents a double bond; one of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is --CH.sub.2 OH, C.sub.2 -C.sub.4 acyl, ##STR7## in which each of R.sub.1, R.sub.8 and R.sub.9 is independently hydrogen or C.sub.1 -C.sub.4 alkyl and the others are independently chosen from hydrogen, hydroxy, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy and --COOR, wherein R.sub.7 is as defined above, and one of R.sub.5 and R.sub.6 is hydrogen and the other is hydrogen, C.sub.1 -C.sub.6 alkyl or phenyl; or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier and/or diluent.

'N-imidazolyl derivatives of bicyclic compounds and pharmaceutical

Compounds of the formula (I) ##STR1## wherein the symbol   represents a single or a double bond;

N-imidazolyl derivatives of bicyclic compounds

Compounds of the formula (I) ##STR1## wherein the symbol   represents a single or a double bond; Z completes a single bond or is a --CH.sub.2 -- group; each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different is

N-Imidazolyl derivatives containing naphthalene or indene nucleus

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Milan, Italy

Germano Carganico