Bio-rad Laboratories, Inc.

Mettler-toledo Rainin, LLC

German Arciniegas

Daniel Y Chu

Richard E Hill

Michael McNaul

Stephen Grimwade

Thomas James McPherson

Charles W Ragsdale

Jeff Ceremony

Paul J Patt

Jeffry M Ceremony

Jason McKee

Eric G Wallace

Jamie Mcpherson

Described are exemplary embodiments of a handheld, powered positive displacement pipette assembly, including a plurality of syringes of different volumes and a powered positive displacement pipette having unique mechanisms for the retention, identification, operation, and ejection of said syringes.

Powered positive displacement pipette assembly

Described are exemplary embodiments of a syringe for use with a handheld positive displacement pipette, the syringe being releasably retainable by the pipette. Syringe embodiments may be configured to hold different material volumes. At least certain syringe embodiments may include a cooperative adapter that is used to releasably couple the syringe to the pipette.

Syringe for powered positive displacement pipette

Described are exemplary embodiments of a handheld, powered positive displacement pipette assembly, including a plurality of syringes of different volumes and a powered positive displacement pipette having unique mechanisms for the retention, identification and ejection of said syringes.

Individual temperature control in multiple reactions performed simultaneously in a spatial array such as a multi-well plate is achieved by thermoelectric modules with individual control, with each module supplying heat to or drawing heat from a single region within the array, the region containing either a single reaction vessel or a group of reaction vessels.

Localized temperature control for spatial arrays of reaction media

Horizontal electrophoresis is performed in a cell that includes a tank and a pair of electrodes, each mounted on an electrode support that is easily inserted into and removed from the tank, and once inserted, is secured in position by one or more spring-loaded, manual-release locking features.

Unitary electrode and electrode support for horizontal electrophoresis

Nonuniformities in the efficiency of detection of individual fluorescing reaction mixtures in a well plate with a two-dimensional array well array are corrected. The nonuniformities arise both from the stimulation pattern and the detection pattern, and are corrected by adding additional segments to a pair of segmented mirrors. The additional segments are oriented to direct light to the outermost reaches (i.e., the four corners) of the array and thereby produce a stimulation pattern that has a greater intensity in the outermost regions. This compensates for a radial decline in the efficiency of the detector in detecting the emissions from the well plate, the radial decline being an artifact of systems that utilize CCDs or similar components as detectors.

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Berkeley, CA, United States of America

German Arciniegas