Compagnie Gervais Danone

Institut National De Recherche Pour L'agriculture, L'alimentation Et L'environnement

Institut National De La Recherche Agronomique

Germain Trugnan

Chantal Cayuela

Jean-Michel Antoine

Miguel Freitas

Philippe Langella

Harry Sokol

Luis G Bermudez-Humaran

Jean-Marc Chatel

Florian Chain

Marie-Anne Maubert

Christophe Michon

Elodie Quevrain

Philippe Seksik

Benedicte Pigneur-Arnaud

Bénédicte Pigneur-Arnaud

Langella Philippe

A method for preventing or treating an inflammatory disease, such as inflammatory bowel disease and Crohn disease, is presented. The method includes administering to a patient a polypeptide having the amino acid sequence of SEQ ID NO: 1, a conservative derivative or a fragment thereof, a nucleic acid sequence encoding said polypeptide, a vector comprising said nucleic acid sequence or a host cell that has been transfected, infected or transformed by said nucleic acid sequence and/or by said vector.

Anti-inflammatory peptides and methods for treating inflammatory diseases

The invention concerns micro-organism strains, in particular of lactic acid bacteria, having a glycosylation modulating effect of intestinal cell surface. The invention also concerns a method for selecting micro-organism strains, in particular of lactic acid bacteria, which consists in measuring the average fluorescence intensity variation of HT29-MTX cells incubated in the presence of a lectin coupled with a fluorochrome after being in contact with the supernatant of the strain concerned. Said lactic acid bacteria strains can be used, optionally in the form of their active fraction, for preparing food compositions or medicines or food supplements, modulating glycosylation of glycoproteins of intestinal epithelial cells.

Microorganisms having intestinal cell surface glycosylation modulating action

Micro-organisms with glycosylation modulating action of intestinal cell surface

Growing community of inventors

Montreuil, France

Germain Trugnan