Sartorius Stedim Biotech Gmbh

Gerid Hellwig

Wilhelm Requate

Oscar-Werner Reif

Thomas Loewe

Stefan Weisshaar

Sebastian Handt

Juergen Van Den Boogaard

Thomas Friese

Jens Ludwig

Johannes Wortmeyer

Andre Dell

Ute Noack

Ulrich Apelt

Juergen Van Den Boogard

André Dell

Jürgen Van Den Boogaard

A disposable filtration device includes a plurality of disposable filter capsules connected with each other by lines, which are carried by a rigid holder. At least the holder and the lines between the filter capsules preferably are formed of a sterilizable material, so that the filtration device can be sterilized in the pre-mounted, i.e. ready-to-connect condition, and can be packed and transported without a risk of damage.

Disposable filtration device

A filtration device () has a housing () and a filter module () with hollow fibers () surrounded by an outer shell (). The hollow fiber bundle () is sealed to the outer shell () at each end by an adhesive () transverse to the longitudinal direction (). Each end of the hollow fibers () is unclosed. An unfiltered product chamber () is between the outer shell () and a wall () of the filter housing () and a filtered product chamber () is inside the filter module (). The bottom end of the filter module () connects with an intermediate section () that connects with a receptacle () of a bottom portion () of the filter housing (). The intermediate section () forms a connection chamber () facing the hollow fiber ends () and radial feed channels () connect the connection chamber () with the unfiltered product chamber ().

Filtration device

Bioreactor with a vessel having at least one gas dissipation duct for gas discharge, the orifice of the gas dissipation duct being connected to a hydrophobic sterile filter and to a condenser arranged between them and having condensation surfaces, a turbulence generator for generating a turbulent flow is arranged in the gas dissipation duct in the region of the condenser.

Bioreactor with condenser

A hollow fiber module (') is made by inserting a bundle of hollow fibers () into a housing (&#x2032;) that has an end closed by a cap (). A fluid first component () that can assume a solid state is introduced into a space adjacent the cap () and forms a spacer into which ends of the hollow fibers () project. A fluid curable second component () is introduced before the first component () via a second inflow () and is cured to form a sealing layer () that embeds the bundle of hollow fibers () and seals it with respect to the adjacent housing wall (&#x2032;). The cap () is removed from the module housing (&#x2032;) along with the first component () and ends of the hollow fibers () embedded in the first component ().

Method for the production of a hollow fiber module, and hollow fiber module

The invention relates to a waste gas system for bioreactors having a hydrophobic sterile filter, arranged at the end, and a heat exchanger which protects the sterile filter against blocking by liquid media. The gas outflow duct for discharging waste gas from a bioreactor vessel is divided in a cooling zone of the heat exchanger into a multiplicity of subducts and is extended in a heating zone of the heat exchanger to a calming zone. Due to the multiplicity of subducts, a considerably larger surface area for the removal of heat from the waste gas is available, with the result that in the case of laminar flow of the waste gas through the subducts a high effectiveness of the separation of liquids from the waste gas can be achieved. In the heating zone, the waste gas can heat up again due to the reduced flow rate until it reaches the hydrophobic sterile filter by way of taking up heat from the surroundings to a such a degree that the relative vapor contents are below 100% and separation of liquids from residual vapors at or in the hydrophobic sterile filter is precluded.

Waste gas system for bioreactors

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Niemetal, Germany

Gerid Hellwig