Boehringer Ingelheim Gmbh

Dr. Karl Thomae Gesellschaft MIT Beschrankter Haftung

Dr. Karl Thomae Gmbh

Gerhart Griss

Rudolf Hurnaus

Wolfgang Grell

Robert Sauter

Bernhard Eisele

Joachim Kahling

Nikolaus Kaubisch

Walter Kobinger

Ludwig Pichler

Eckhard Rupprecht

Matyas Leitold

Manfred Kleemann

Richard Reichl

Walter Haarmann

Hanns Ihrig

Lothar Benedikter

There are described novel carboxylic acid derivatives of the formula ##STR1## and derivatives of the formula ##STR2## and the addition salts thereof, which exhibit an effect on the intermediary metabolism. Furthermore, the compounds of Formula Ia as well as the compounds of Formula I possess blood-sugar lowering properties.

Carboxylic acid amides and pharmaceutical compositions containing them

Compounds of the formula ##STR1## wherein A and B, which may be the same or different, each represent methylene, (alkyl of 1 to 3 carbon atoms)-methylene, ethylene or (alkyl of 1 to 3 carbon atoms)-ethylene;

Fused-ring amino-pyrazines as bradycardiacs

Compounds of the formula ##STR1## wherein n and m are each 1, 2 or 3, and the sum of n+m is 4;

Azepine derivatives and their anti-thrombotic compositions and methods

Fused-ring amino-pyrazines as bradycardiac agents

This invention relates to novel indole derivatives of formula ##STR1## and the non-toxic, pharmacologically acceptable salts thereof. These compounds exhibit desirable pharmacological properties, especially lipid-level lowering and anti-atherosclerotic activity. The compounds of the invention may be prepared by, for example, alkylation of a corresponding hydroxy indole.

2[3-(4-Chlorophenyl)-1,2-dimethyl-1H-indol-5-yloxy]-2-methyl propanoic

Antianginal pharmaceutical compositions containing as the active ingredient a compound of the formula ##STR1## wherein R.sub.1 is hydrogen, unsubstituted or hydroxyl-substituted alkyl of 1 to 4 carbon atoms; allyl; or unsubstituted or halo-, methyl-, methoxy- or trifluoromethyl-substituted benzyl; and

Antianginal treatment with azepine derivatives

Compounds of the formula ##STR1## wherein R.sub.1 is straight or branched alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, phenylalkyl, phenylalkenyl, pyridyl or ##STR2## where X, Y and Z are each hydrogen, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms,

Derivatives of biphenyloxy-lower alkanoic acids, salts thereof and their

Biphenyloxy derivatives and antihyperlipidemic use

Pharmaceutical dosage unit compositions containing as an active ingredient a compound of the formula ##SPC1## Wherein

Pharmaceutical compositions containing a 1-phenyl-2,2,4,4-C.sub.1

Compounds of the formula ##SPC1## Wherein ##EQU1## where R.sub.1 is hydrogen, straight or branched aliphatic acyl of 1 to 12 carbon atoms, methoxy-substituted straight or branched aliphatic acyl of 1 to 12 carbon atoms, benzoyl, halo-benzoyl, carbalkoxy of 2 to 7 carbon atoms, carbcycloalkoxy of 4 to 7 carbon atoms, benzyl, methylbenzyl, phenylsulfonyl, halo-phenylsulfonyl, tolylsulfonyl, alkenyl of 2 to 6 carbon atoms, phenyl, trifluoroacetyl, amidino, amido, thioamido, phenoxycarbonyl, benzyloxycarbonyl, methylsulfonyl or

Tetrahydro-azepinoquinolines

This invention relates to cyclobutane derivatives having the formula ##SPC1## Wherein R.sub.1 to R.sub.3, which may be the same or different, represent hydrogen atoms, halogen atoms, hydroxy, trifluoromethyl, benzyloxy, acyloxy groups, alkyl groups with 1 to 6 carbon atoms, alkoxy groups with 1 to 3 carbon atoms, phenyl, cyclohexyl, or 2 of the radicals R.sub.1 to R.sub.3 together represents a methylenedioxy group,

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Biberach, Germany

Gerhart Griss