Hoechst Aktiengesellschaft

Riedel-de Haen Aktiengesellschaft

Etc C.v.

Gerhard Wohner

Rudiger Marquardt

Alfred Puhler

Wolfgang Wohlleben

Susanne Grabley

Klaus Bartsch

Johann Then

Renate Alijah

Dieter Brauer

Eckhard Strauch

Walter Arnold

Hans-Matthias Deger

Wolfgang Lindner

Hartmut Voelskow

Gert-Wolfhard Von Rymon Lipinski

Gunter Muth

Erich Taschenbrecker

Erich Luck

Martyn K Robinson

Andreas Lotz

Merten Schlingmann

Reinhold Keller

Klaus Kuhlein

Gerhard Kretzschmar

Dieter Duwel

Peter Hammann

Paul Prave

Hans Gattner

Martin Platen

Stefan E Scheuermann

Christian Klug

Jorg Rothermel

Hans-Dieter Pries

Karl Wagner

Evelyn L Doherty

Andrew Doherty

Algicide combination

Selection of Streptomyces viridochromogenes DSM 4112 for resistance to phosphinothricyl-alanyl-alanine (PTT) results in PTT-resistance selectants. The DNA fragment which carries the phosphinothricin(PTC)-resistance gene is obtained from the total DNA of these selectants by cutting with BamHI, cloning of a fragment 4.0 kb in size, and selection for PTT resistance. This gene is suitable for the production of PTC-resistant plants, and as a resistance marker and for the selective N-acetylation of the L-form of racemic PTC.

Phosphinothricin-resistance gene, and its use

It has been found that bacteriolytic enzyme products and proteases can be added in a mixture as additive to feedstuffs, whereby an improvement in feed conversion, manifested by improved growth of the livestock, is brought about.

Use of bacteriolytic enzyme product and protease as additive for

The present invention relates to the use of methylthiocyclopropylamino-tert.-butylamino-1,3,5-triazine (Mctt) as a microbicidal agent for the treatment of concrete roof tiles.

Use of a microbicidal agent for the treatment of concrete roof tiles

The ilvE gene from the strain E. coli ATCC 11303 is suitable for achieving overproduction of the coded aliphatic transaminase and thus for preparing the branched-chain amino acids leucine, isoleucine and valine from the corresponding keto precursors.

Cloning and use of the transaminase gene ilvE

The invention relates to elaiophylin derivatives of the formulae (I), (I'), (III) and (III') ##STR1## in which the C.dbd.C double bonds in the 2,3 and 4,5 position may also be hydrogenated and in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X have the meanings indicated. The invention furthermore relates to a process for the preparation of these elaiophylin derivatives, and the use thereof as pharmaceuticals, in particular as anthelmintic pharmaceuticals.

Basic cleavage products of elaiophylin and elaiophylin derivatives and

The isolation of the tyrB gene contained in E. coli ATCC 11303 and its cloning onto a multicopy plasmid results in a 10-fold increase in the L-phenylalanine yield after the transformation of the starting strain with this plasmid.

Cloning and use of transaminase gene tyrB

Intensely crimson colonies are obtained from Streptomyces coelicolor DSM 3030 by total digestion of the total DNA, cloning into a suitable vector, and transformation of Streptomyces lividans. Re-isolation of the plasmid DNA and cutting with BamHI results in fragments about 3.4 to 9 kb in length, on which is located the gene which determines production of the coloring agent. This gene is suitable as marker, in particular as inactivation marker, in Streptomycetes.

Color marker for clonings in Streptomyces lividans

Intensely blue-black colonies are obtained from Streptomyces coelicolor DSM 3030 by total digestion of the total DNA, cloning into a suitable vector, and transformation of a streptomycetes recipient strain. Re-isolation of the plasmid DNA and cutting with BamHI results in a 5.5 kb fragment on which the gene for the coloring agent is located. This gene is suitable as marker, in particular as inactivation marker, in Streptomycetes.

Color marker in streptomycetes plasmids

A bacteria-lysing enzyme product from streptomycates can preserve poultry and fresh meat products. It effects a reduction in the organism count, by acting not only on Gram-positive organisms but also on Gram-negative bacteria such as, for example, Enterobacteriaceae.

Process for preserving raw meat with a bacteria-lysing enzyme from

The strain Streptomyces coelicolor DSM 3030 excretes into the fermentation medium high yields of a bacteriolytic enzyme product which is very active against Gram-positive and Gram-negative bacteria. Preferred fermentation media contain sugar beet molasses and/or calcium ions.

Bacteriolytic enzyme product from streptomyces, a process for its

L-Phenylalanine can be prepared using microorganisms belonging to the series comprising E. coli, Paracoccus denitrificans, Torula, Rhodotorula or Streptomyces after adaptation to phenylpyruvic acid, by amination with suitable sources of nitrogen. It is advantageous to employ the microorganism in the form of fixed cells.

Process for the preparation of L-phenylalanine

Growing community of inventors

Florsheim am Main, Germany

Gerhard Wohner