Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

Boehringer Mannheim Gmbh

Roche Diabetes Care, Inc.

F. Hoffmann-la Roche Ag

Gerhard Werner

Hans-Peter Haar

Dirk Boecker

Herbert Harttig

Wolfgang Petrich

Hans-Juergen Kuhr

Heinz-Michael Hein

Arnulf Staib

Reinhold Mischler

Ortrud Quarder

Dirk Bocker

Joachim Kastner

Armin Lambrecht

A method is provided for evaluating a set of measurement data from an oral glucose tolerance test. The method may include calculating a similarity measure that quantifies the similarity between a time profile of the series of measured data of the glucose concentration and a corresponding glucose reference profile. The method may include calculating a further similarity measure that quantifies the similarity between the profile of the series of measured values of the further analyte concentration and the corresponding analyte sample profile, wherein the data set is represented by a point in a vector space that comprises coordinate axes that are formed by the similarity measures, whereby the coordinates of said point contain the calculated values of the similarity measures. The method also may include evaluating the position of the point with respect to reference points, which each represent a defined state of health, in order to calculate a parameter that specifies the state of the glucose metabolism of the patient.

Method for evaluating a set of measurement data from an oral glucose tolerance test

Methods and devices for analyzing body fluids, in particular for determining blood glucose. Body fluid is applied to a test element for single-use in a test device and the test element is optically coupled to a photometric measuring unit by means of an optical transmission system, wherein a time course of measuring values is recorded after the body fluid has been applied in order to detect a component of the body fluid on the test element. The transmission behavior of the optical transmission system may be controlled by recording measuring values at two different measurement wavelengths.

Method and device for analyzing a body fluid

A sensor is described for optically determining the concentration of an analyte in a body fluid. This sensor comprises a needle arrangement which has at least one hollow needle having a hollow space extending from the distal end to the proximal end, the distal end of which is suitable for lancing. The proximal end of the needle opens into a chamber in which liquid that enters through the distal end of the needle can be collected. A window which is at least partially permeable to infrared radiation is in direct contact with the chamber.

Microneedle arrays with ATR sensor

The invention relates to analysis methods for diagnosing diseases on human and animal samples. Said invention also relates to an evaluation method for diagnosing the individual stages of a disease in such a way that it is possible to display the progression thereof. Said invention also makes it possible to identify diseases in an early manner and to carry out therapeutic controls. The inventive method consists in carrying out actually known multivariable evaluation methods for classifying samples. Nevertheless, the invention is characterised in that no sample is allocated to a certain class, but it is classified in a data record based on the interpolation between different classes.

Quantification of disease progression by means of interpolation between parameters based on electromagnetic spectra

Analysis device for determining an analyte in vivo in the body of a patient, having a measuring probe with a hollow needle ( ) which can pierce through the skin. Light is passed through the hollow needle ( ) and into the body via an optical fiber ( ) travelling in the hollow needle ( ). The light transported in the optical fiber ( ) is modified in the measuring probe ( ), the modification being characteristic of the presence of the analyte. A measurement and evaluation unit ( ) measures the change to extract information concerning the presence of the analyte in the body. The hollow needle ( ) is permeable, at least in a partial section of its length, serving as a measuring section ( ) which can be inserted into the skin so that interstitial liquid may penetrate through the hollow needle wall to a measuring section of the optical fiber extending in the hollow needle ( ) and the modification of the light characteristic of the presence of the analyte is effected through interaction with the interstitial liquid in the measuring section.

Analytical device for in vivo analysis in the body of a patient

Sample carrier for use in infrared transmission spectroscopy

Quantitative transmission spectroscopy where a sample liquid is applied onto a sample carrier having a net in such a manner that the liquid spreads across the meshes of the net. The liquid on the net is exposed to radiation essentially perpendicularly to the net, and the transmitted radiation is detected. The net accomplishes a dosing of the liquid in such a manner that identical meshes include identical quantities of liquid. For a given net, it is possible to derive the amount of liquid, which is located in a mesh and accessible to radiation, from a net constant. Knowing the amount of liquid detected by the radiation, it is possible to use the radiation absorption to calculate the concentration of one or several analytes contained in the sample liquid.

Quantitative transmission spectroscopy using sample carriers with nets

Growing community of inventors

Weinheim, Germany

Gerhard Werner