Jenapharm Gmbh

Gerhard Teichmuller

Gerd Muller

Michael Oettel

Sigfrid Schwarz

Bernd Undeutsch

Gunter Kaufmann

Doris Hubler

Ronald Gebuhr

Harry Henkel

The 17.alpha.-cyanomethylestra-4,9-diene derivative compounds are of formula I: ##STR1## wherein R.sub.1 is an alkyl group having from 1 to 2 carbon atoms; R.sub.2 is an alkyl group with 1 to 10 carbon atoms, an acyl group with 1 to 10 carbon atoms or a trialkylsilyl group; and R.sub.3 is an oxygen atom or a R--O--N group, wherein R is a hydrogen atom, an acyl group with 1 to 10 carbon atoms, an alkyl group with 1 to 10 carbon atoms, a sulfamoyl group, an alkylsilyl group or a trialkylsilyl group. These compounds, particularly in combination with at least one suitable estrogen, are suitable for treatment of endometrioses or gestagen-dependent tumors and for hormonal contraception and climacteric hormone replacement therapy (HRT). Processes for making the new steroids are described as well as methods of making the pharmaceutical compositions containing them.

17.alpha.-cyanomethylestra-4,9-dien derivatives and pharmaceutical

Process for the production of unsaturated 17 .alpha.-cyanomethyl-17 .beta.-

Growing community of inventors

Jena, Germany

Gerhard Teichmuller