Dsm Fine Chemicals Austria Nfg Gmbh & Co. Kg

Hoffmann-la Roche Inc.

Dsm Chemie Linz Gmbh

Gerhard Steinbauer

Peter Pojarliev

Helmut Schwab

Wolfgang Skranc

Harald Pichler

Marcel G Wubbolts

Martina Kotthaus

Erich Steinwender

Christoph Zenzmaier

Manuela Hermann

Joannes Kierkels

Micheal Stanek

Heinrich Horacek

Andreas Hendrikus Maria De Vries

Gerhard Stern

Laurent Lefort

Johannes Gerardus De Vries

Peter Hildebrand

Klaus Reiter

Karlheinz Giselbrecht

Michael Stanek

Anna Maria Cornelia Francisca Castelijns

Stefaan Marie Andre De Wildeman

Christian Burger

Gerald Summer

Ernst Kupfer

Ulfried Felfer

Curt Zimmermann

Sylvia Krich

Ferdinand Heu

Ernst Wressnegger

Stephan Doswald

Henricus Martinus Maria Gerardus Straatman

Andreas H M De Vries

Otto Vogl

Klaus Edegger

Jan Bartus

Manfred Sch&ouml;ftner

Regina Schitter

Alexander Rieder

Jeroen Boogers

Marcel Wubbolts

Peter c/o Dsm Fine Chemicals Austria Pojarliev

Christian c/o Dsm Fine Chemicals Austria Burger

Polypeptide and recombinant protein having esterase activity which exhibit the amino acid sequence SEQ. ID. No. 1 and the use thereof.

Polypeptide having esterase activity and recombinant esterase and use thereof

Method of resolving stereoselectively racemic 2-alkyl-5-halopent-4-ene-carboxylic esters of the formula (I) 

This invention relates to novel alpha-substituted &#x3b1;,&#x3b2;-unsaturated E- or Z-aldehydes, or isomer mixture thereof, of the formula (I) in which Rand Rmay be identical or different and are each H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms and Rand Rmay be identical or different and are each a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, and Rmay be identical or different and is H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, to the use thereof, and to processes for their preparation. The invention further relates to the preparation of further intermediates for pharmaceuticals and to the preparation of the pharmaceuticals. 

Alpha-substituted &#x3b1;,&#x3b2;-unsaturated E- or Z-aldehydes, use thereof, and processes for their preparation &#x3b1;,&#x3b2;

A process for preparing racemic alkyl-5-halopent-4-enecarboxylic acids and esters thereof of the formula (I), in which R is a C-C-alkyl radical, Ris H or C-alkyl and X is chlorine, bromine or iodine, which comprises a) reacting a dialkyl alkylmalonate of the formula (II),in which R is as defined above and Ris a C-C-alkyl radical, in the presence of a metal alkoxide of the formula MOR, in which M may be Na, K or Li, and Ris a C-C-alkyl radical, and in an organic solvent, with 1,3-dihalopropene to give the corresponding allylated malonate, then b) after full conversion, adding an inorganic salt and a C-Calcohol to the reaction mixture, heating the reaction mixture to reflux temperature, then c) isolating the desired racemic ester of the formula (I) from the reaction mixture by extraction or direct distillation and d) if the racemic acid is the desired end product, hydrolyzing the ester function. 

Process for preparing racemic alkyl-5-halopent-4-enecarboxylic acids or carboxylic esters

A process for transition metal-catalyzed, asymmetric hydrogenation of acrylic acid derivatives of the formula (I) in which R1 is H or an optionally substituted alkyl, aryl or heteroaryl radical, R2 is an optionally substituted alkyl, aryl or heteroaryl radical, and R3 is H or a C-C-alkyl radical, which comprises hydrogenating compounds of the formula (I), optionally in a solvent, in the presence of one or more hydrogen donors, using a catalyst system which comprises a transition metal from the group of ruthenium, rhodium and iridium and a combination of a chiral phosphorus ligand of the formula (II) in which Cn, together with the two oxygen atoms and the phosphorus atom, forms an optionally substituted ring having from 2 to 6 carbon atoms and R4 is an optionally substituted alkyl, aryl, alkoxy or aryloxy radical or NR5R6 where R5 and R6 may each independently be H or an optionally substituted alkyl, aryl, aralkyl or alkaryl radical, or, together with the nitrogen atom, may form a ring, and an achiral phosphine ligand of the formula (III) in which R is an optionally substituted alkyl or aryl radical, to the corresponding compounds of the formula (IV) in which R1, R2 and R3 are each as defined above, and also a novel catalyst system for asymmetric transition metal catalysis.

Process for transition metal-catalyzed asymmetric hydrogenation of acrylic acid derivatives, and a novel catalyst system for asymmetric transition metal catalysis

Process for the preparation of substituted thiazolines of the formula (I)in which Ar is a phenyl, naphthyl, thienyl, pyridyl or quinolinyl radical which can optionally be substituted by one or more substituents from the group consisting of halogen, OH, benzyloxy, C-C-alkyl, C-C-alkoxy, COORwhere Ris H or C-C-alkyl,by coupling of (S)-&#x3b1;-methylcysteine hydrochloride of the formula (II)with a nitrile of the formula (III)Ar&#x2014;CNin which Ar is as defined above, or a corresponding C-C-alkyl imidate, in which (S)-&#x3b1;-methylcysteine hydrochloride of the formula (II) is reacted in a suitable solvent with a nitrile of the formula (III) or a corresponding C-C-alkyl imidate in the presence of a tertiary base at a pH of 6.5 to 10 at 50&#xb0; C. up to the reflux temperature to give the corresponding thiazoline of the formula (I), and processes for the preparation of (S)-&#x3b1;-methylcysteine hydrochloride and its use for the preparation of thiazolines of the formula (I).

Process for the preparation of substituted thiazolines and their intermediates

The invention relates to a washing process for cleaning polymers containing N or amine, ammonium or spirobicyclic ammonium groups, comprising cationic groups containing N, in addition to suitable counterions, whereby the gelled-out polymers are obtained through polymerization and cross-linking by a) adding a base which is partially or fully deprotonated, b) the partially or fully deprotonated polymers are washed, then c) optionally, are reprotonated in an organic solvent or in an organic solvent/water mixture by adding an acid, whereupon d) optionally, they are washed in an organic solvent or an organic solvent/water mixture in order to shrink the gels and optionally, e) in connection with step c) or d), the steps a)-c) or -d) are repeated.

Washing process for the purification of polymers containing N or amino, ammonium or spirobicyclic ammonium groups

Process for preparing substituted aromatic and heteroaromatic aldehydes and carboxylic acids

An improved process for the preparation of substituted pyridinecarboxylic acids (II), useful as herbicide intermediates, by ozonolysis of quinolines (I).

Method for producing substituted pyridine-carboxylic acids

The present invention relates to a method for the purification of the lipstatin. Impurities are removed from a lipstatin preparation by: a) mixing the preparation with a polar phase and to form a first two phase system in which the ratio of the lipstatin to the non-polar impurities in the polar phase is greater than in the preparation, and separating the phases from the first two phase system and collecting the lipstatin-enriched polar phase, and b) i) diluting the lipstatin-enriched polar phase from step a) with water to form a diluted lipstatin-enriched polar phase containing the polar solvent in a percentage of at least seventy percent of the polar phase and lower than in the lipstatin-enriched polar phase from step a), and mixing the diluted lipstatin-enriched polar phase with a second non-polar phase, the second non-polar phase being the same non-polar solvent as the first non-polar phase in the same or greater relative amount to the polar phase as in the first two phase system; or ii) mixing the lipstatin-enriched polar phase from step a) with a second non-polar phase, the second non-polar phase being the same non-polar solvent as the first non-polar phase in a greater relative amount to the polar phase as in the first two phase system; to form a second two phase system in which the ratio of the lipstatin to the polar impurities in the second non-polar phase is greater than in the lipid-enriched polar phase from step a), and separating the phases from the second two phase system and collecting the lipstatin-enriched second non-polar phase.

Purification of lipstatin

2,6-dimethylphenylmaleimide is used as a comonomer for the preparation of styrene copolymers and vinyl chloride copolymers having an increased glass transition temperature and low intrinsic coloration compared with the prior art.

2,6-dimethylphenylmaleimide as a comonomer for styrene copolymers and

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Enns, Austria

Gerhard Steinbauer