American Cyanamid Company

Gerhard Schlingmann

Robert J West

David P Labeda

Guy T Carter

Joseph J Goodman

E B Jones

Cedric J Pearce

Stuart A Rosenfeld

David A Albaugh

Cedric John Pearce

Lisa Milne

New antibacterial agents produced by fungal culture 07F275, of which the compound designated 07F275 alpha having the following structure: ##STR1## is representative. Methods for the fermentation, recovery and purification from crude solutions are also disclosed.

Isolation, characterization and structures of new antibiotic components

This invention provides new antifungal compounds of Formula I or II: ##STR1## wherein R, R.sup.1 and R.sup.2 are defined in the specification produced by culture LL-15G256 (Hypoxylon oceanicum), NRRL 21363 and their production by fermentation and use as antifungal agents.

Fungicidal agents LL-15G256.gamma.,.delta., and .epsilon. produced by

This invention relates to antibiotic LL-D37187.alpha. derived from the microorganism Streptomyces which is useful as an antibacterial agent.

Antibiotic LL-D37187.alpha.

A process for the preparation of optically pure diastereoisomers of tetrahydrofolate compounds is described, comprising the conversion, for example, of only the 5,6S,7,8-tetrahydrofolic acid component of a racemic mixture of 5,6,7,8-tetrahydrofolic acid to 10-formyl-5,6S,7,8-tetrahydrofolic acid in the presence of a formyl tetrahydrofolate synthetase, followed by cyclizing, hydrolyzing and derivatizing. The process is also useful to make a desired substantially pure (6R or 6S) enantiomer of a derivative of (radiolabeled) tetrahydrofolic acid or a salt or ester thereof.

Process for the preparation of optically pure diastereoisomers of

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Hillburn, NY, United States of America

Gerhard Schlingmann