Other

K.u. Leuven Research & Development

Gilead Sciences, Inc.

Puerstinger, Gerhard

Gerhard Puerstinger

David A Oare

Steven S Bondy

Choung U Kim

Johan Neyts

Eric Davis Dowdy

Pyrrolo[2,3-c]pyridine or pyrrolo[3,2-c]pyridine compounds having the general formula (A), wherein the dashed lines, X, Y and Rthrough Rare as defined in the specification. The compounds are useful in the prophylaxis or treatment of viral infections.

Viral inhibitors

The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one compound having the general formula (A): wherein U is N or C; X is selected from C-Calkylene, Calkenylene or Calkynylene, where each may include one or more intrachain heteroatoms selected from O, S, or NR, provided any such heteroatom is not adjacent to the N in the ring; Ris selected from aryl, aryloxy, arylthio, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl-N(R)&#x2014;, or heterocycle, where each said substituent is optionally substituted with at least one R, provided that for cycloalkenyl the double bond is not adjacent to a nitrogen; and the other substituents are described in the specification. The invention also relates to processes for the preparation of compounds according to the invention having above mentioned general formula, their pharmaceutically acceptable formulations and their use as a medicine or to treat or prevent viral infections.

Imidazo[4,5-d]pyrimidines, their uses and methods of preparation

Growing community of inventors

Igls, Austria

Gerhard Puerstinger