Solvay Pharmaceuticals, Gmbh

Abbott Products Gmbh

Gerhard Kristen

Bernd Thumbeck

Ingo Bonnacker

Klaus Budde

Margit Wiards

Christine Reichel

Hartmut Koehn

A pharmaceutical matrix film tablet with controlled release of natural mixtures of conjugated estrogens which have been obtained from the urine of pregnant mares.

Matrix film tablet with controlled release of a natural mixture of conjugated estrogens

Solid and liquid pharmaceutical preparations containing cilansetron or its acid addition salts as active substance which include an amount sufficient to stabilize cilansetron against racemization, of a physiologically compatible water-soluble acid additive selected from monobasic or multibasic organic acids having 2 to 12 carbon atoms with a first p.sub.s value between 1.1 and 4.8, acid salts of the aforementioned multibasic organic acids, and acid salts of multibasic mineral acids having a first available pK.sub.s value between 1.5 and 7.5, as well as the use of such acid additives for stabilizing cilansetron against racemization in pharmaceutical preparations.

Cilansetron pharmaceutical preparation stabilized against racemization

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Burgdorf, Germany

Gerhard Kristen