Basf Aktiengesellschaft

Knoll Aktiengesellschaft

Gerhard Keilhauer

Cynthia A Romerdahl

Xiao-Dong Qian

Marina Moran Moset

Miguel Fernandez Brana

Lothar Daum

Peter Bousquet

Bernd Janssen

Kurt Ritter

Heinz Hillen

Achim Moeller

Franz Emling

Jose Maria Berlanga

Thomas Doerper

Miguel F Bra Na

Eberhard Ammermann

Gisela Lorenz

Andreas Kling

Andreas Haupt

Dagmar Klinge

Teresa Barlozzari

Rainer Schlecker

Wolfgang Steglich

Jose Maria Castellano Berlanga

Wolfgang Koerwer

Erich Schlick

Stefan Mueller

Jose Mc Berlanga

Angela Scherer

Maria Jesus De Vega

Maria Jp De Vega

Wolfgang Weber

Maria Jesus Perez De Vega

Bert Steffan

Klaus Schollmeier

Mar Ia P Erez De Vega

Jos E Berlanga

Ulrich Traugott

Disclosed herein are compounds pharmaceutical compositions containing same of the formula

Bis-naphthalimides for the treatment of cancer

Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula ##STR1## wherein X, X', X' and X'', A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutical compositions containing same can be used in the treatment of cancer.

This invention relates to 1-amino-3-phenoxy-propane-derivatives of formula 1: ##STR1## (in which A, B, R, R.sup.x, X and Z are defined as in the specification described) and methods for their preparation. These compounds may be used as modulators of multidrug resistance in cancer chemotherapy and for circumvention of resistance in the treatment of malaria.

1-amino-3-phenoxy propane derivatives as modulator agents and their

Asymmetrically substituted bisnaphthalimides

Novel peptides of the formula ##STR1## in which R.sup.1, R.sup.2, X, A, R.sup.3, B, D, E, R.sup.7, M, Q, a, b and d have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.

Peptides, the preparation and use thereof

Derivatives of a tumor necrosis factor (TNF), which originate from a modification at the amino terminus of the TNF molecule are suitable for controlling diseases.

Proteins having a TNF action comprising TNF-fibromectin fusion protein

Polypeptides which differ from lymphotoxin by the absence of amino acids at the N-terminal end of the lymphotoxin are described. The polypeptides can be prepared by gene manipulation and are suitable, alone or in combination with lymphokines, as pharmaceuticals.

N-terminal deletions of lymphotoxin, their preparation and use

Novel strobilurine derivatives which are suitable for the treatment of disorders and as fungicides are described.

Novel strobilurine derivatives, their preparation and their use

Bisnaphthalimides of the formula I ##STR1## where X.sup.1 to X.sup.4 and R have the meanings stated in the description, and their preparation are described. The compounds are cytotoxic towards human cells in vitro.

Bisnaphthalimides

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Dannstadt-Schauernheim, Germany

Gerhard Keilhauer