Hoechst Aktiengesellschaft

Gerhard Huber

Peter Schindler

Hans-Wolfram Fehlhaber

Hans G Berscheid

Hans-Harald Sedlacek

Laszlo Vertesy

Werner Aretz

Bimal N Ganguli

Hans P Kraemer

Julia Gandhi

Gauknapalli C Reddy

Ratan S Sood

The present invention relates to anthracyclin derivatives of the formula I ##STR1## in which R.sub.1 and R.sub.2 are identical or different and represent the sugar residue Roa (L--rhodosamine) of the formula ##STR2## or the sugar combination Roa--dF.dbd.CinB (dF=2-deoxy-L-fucose; CinB.dbd.L-cinerulose B) of the formula ##STR3## The invention furthermore relates to a process for the preparation of the above compounds of the formula I, and to their use as cytostatic agents.

Anthracyclin derivatives

The present invention relates to the micro-organism Streptomyces purpurascens (DSM 2658), its mutants and variants, a process for the preparation of anthracycline derivatives by fermentation of these cultures and to the anthracycline derivatives themselves. The new compounds are distinguished by antibacterial activity and, in addition, they act against various types of tumors.

Anthracycline derivatives and their use as cytostatics

A method for isolating a chemically unstable carbapenem antibiotic from a fermentation solution by adsorbing the antibiotic on an ion exchanger resin at the maximum of product formation, thus converting it to a stabilized form, and then separating the resin from the fermentation solution.

Isolation of chemically unstable antibiotics from fermentation solutions

A chromophoric cephalosporin composition having the formula ##STR1## is utilized for the detection of .beta.-lactamases. Detection of .beta.-lactomases can be carried out by diluting the compound in solution or by a test strip carrier.

Detection of .beta.-lactamase utilizing a chromophoric cephalosporin

What are disclosed are cephalosporins of the formula ##STR1## processes for the manufacture of said cephalosporins, preparations containing same for the detection of .beta.-lactamases, a process for making said preparations, and the use of said cephalosporins for the detection of .beta.-lactamases.

Chromophoric cephalosporins

A novel process for obtaining cephalosporin C and the salts and derivatives thereof from culture filtrates or culture solutions is provided which comprises drying the culture filtrate or culture solution, dissolving it in an optionally water-containing solvent different from water, and

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Kelkheim, Germany

Gerhard Huber