Dr. Karl Thomae Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Karl Thomae Gmbh

Boehringer Ingelheim Pharma Kg

Karl Thomas Gmbh

Gerhard Hallermayer

Klaus Rudolf

Henri Doods

Wolfgang Eberlein

Wolfhard Engel

Michael Mark

Roland Maier

Ralph-Michael Budzinski

Peter Muller

Rudolf Hurnaus

Eberhard Woitun

Bernhard Eisele

Wolfgang Wienen

Helmut Pieper

Michael Entzeroth

Eckhart Bauer

Bernard Eisele

Leo Thomas

Rudolph Hurnaus

The present invention relates to modified amino acids of general formula whereinA, Z, X, n, m, R, R, R, Rand Rare defined as in claimsto, their tautomers, their diastereomers, their enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them as well as their use for the production and purification of antibodies and as labelled compounds in RIA- and ELISA assays and as diagnostic or analytical aids in neurotransmitter research.

Modified amino acids, pharmaceuticals containing these compounds and method for their production

A compound of general formula (I) wherein R and Rare as defined herein, or a tautomer, diastereomer, enantiomer, or salt thereof, particularly the physiologically acceptable salts thereof, which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing the compound, their use, and processes for preparing them.

Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof

The present invention relates to compounds of general formulaR&#x2014;Z&#x2014;Z&#x2014;Z&#x2014;R, &#x2003;&#x2003;(I)wherein

Arylalkane, arylalkene and aryl azaalkane, medicaments containing said compounds and method for the production thereof

Modified aminoacids, pharmaceuticals containing these compounds and method for their production

Antagonists of calcitonin gene-related peptide

Compounds that inhibit the enzyme 2,3-epoxysqualene-lanosterol-cyclase and cholesterol biosynthesis, of the formula I ##STR1## wherein n denotes the number 0 or 1, m denotes the number 1 or 2, p denotes the number 0 or 1, R.sup.1 and R.sup.2 each denote hydrogen, lower alkyl, alkenyl or alkynyl, which may optionally also be substituted, or together with the nitrogen atom between the denote 5- to 7-membered saturated, monocyclic or heterocyclic rings which may optionally also be interrupted by an oxygen or sulfur atom or by an imino group, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 denote hydrogen or lower alkyl, R.sup.5 additionally denotes lower alkoxy, R.sup.7 denotes hydrogen, cycloalkyl, phenyl or substituted phenyl, naphthyl, tetrahydronaphthyl, thienyl, furyl or pyridyl and A denotes a chemical bond or alkyl, alkenyl having up to 17 carbon atoms.

O-acyl-4-phenyl-cyclohexanols, their salts, medicaments containing such

Benzothiazoles and benzoxazoles, drugs containing them, their use and

The invention relates to arylidene-1-azacycloalkanes and arylalkyl-1-azacycloalkanes of the general formula ##STR1## (wherein n, m, p, A, W.sup.1, W.sup.2, X, Y, and R.sup.1 to R.sup.11 are as defined in claim 1) and the isomers, isomer mixtures and salts thereof, which have useful properties, in particular an inhibitory effect on cholesterol biosynthesis.

Arylidene-1-azacycloalkanes and arylalkyl-1-azacyclo-alkanes, their

The invention relates to N,N-disubstituted arylcycloalkylamines of general formula ##STR1## wherein n, m, A, X and R.sup.1 to R.sup.7 are defined as in claim 1, the isomers, isomer mixtures and salts thereof, which have valuable properties, particularly an inhibitory effect on cholesterol biosynthesis.

N,N-disubstituted arylcycloalkylamines, the salts thereof,

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Maselheim-Sulmingen, Germany

Gerhard Hallermayer