Byk Gulden Lomberg Chemische Fabrik Gmbh

Altana Pharma Ag

Nycomed Gmbh

Gerhard Grundler

Beate Schmidt

Geert Jan Sterk

Bernhard Kohl

Georg Rainer

Armin Hatzelmann

Wolf-Rudiger Ulrich

J&ouml;rg Senn-Bilfinger

Steffen Weinbrenner

Josef Stadlwieser

Ulrich Kilian

Ulrich Thibaut

Peter Jan Zimmerman

Peter Zimmermann

J Org Senn-Bilfinger

The compounds of formula I in which the given substituents have the meanings as given in the description, are novel effective PDE4 inhibitors.

Phthalazinone-piperidino-derivatives as PDE4 inhibitors

The compounds of formula Iin which R1, R2, R3, A, X, s and R9 have the meanings as given in the description are novel effective PDE4 inhibitors.

Piperazino-derivatives and their use as PDE4 inhibitor

The compounds of a formula I, in which the given substituents have the meanings as given in the description, are novel effective PDE4 inhibitors

3,4-Dihydroisoquinoline and isoquinoline compounds of formula I, in which Ar represents a phenyl raidcal of the formulae IIa, IIb or IIc are novel effective PDE7 inhibitors.

(Dihydro) isoquinoline derivatives as phosphodiesterase inhibitors

Benzylaminopyrimidine compounds of a certain general formula I, in which the substituents and symbols are as defined in the description, are suitable for controlling Helicobacter bacteria.

Benzylaminopyrimidines

Compounds of formula (I) in which the substituents and symbols have the meanings indicated in the description, are suitable for the control of Helicobacter bacteria.

Quinoline-aminomethyl-pyridyl derivatives with anti-helicobacter activity

The present invention relates to compounds of formula (I) wherein R1, R2, and R3 are hydrogen, 1-4C-alkyl, or halogen; R4, R5, R6, and R9 are hydrogen or 1-4C-alkyl; R7 and R8 are hydrogen, 1-4C-alkyl, 1-4C-alkoxy, or halogen; A is 1-7C-alkylene, 2-7C-alkenylene, 3-7C-cycloalkylene, or phenylene; G is hydrogen, hydroxyl, 1-7C-alkyl, 1-4C-alkyl substituted by fluorine, 2-7C-alkenyl, 3-7C-cycloalkyl, a mono- or di-1-4C-alkylcarbamoyl or -thiocarbamoyl, N-1-4C-alkyl-N&prime;-cyanoamidino, 1-N-1-4C-alkylamino-2-nitroethylene, N-2-propynyl-N&prime;-cyanoamidino, aminosulfonylamidino, &mdash;N(R10)R11, the part of the compound of formula (I) bonded to A, glucopyranoside, or a cyclic system or bicyclic system which is optionally substituted by R12 and R13; X is oxygen, N-1-4C-alkyl, NH, or S; Y is oxygen, N-1-4C-alkyl, NH, S, 1,4-piperazinylene, or 1,4-piperidinylene; Z is oxygen, N-1-4C-alkyl, NH, S, or CO; m is from 1 to 7; n is from 0 to 4; t is 0, 1, or 2; and u is 0 or 1, and their salts suitable for controlling Helicobacter bacteria.

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Constance, Germany

Gerhard Grundler