Octapharma Ag

Gerhard Gruber

Djuro Josic

Monika Stadler

Juergen Roemisch

Anton Reschny

Kim Bjornstrup

Martin Kern

Andrea Heger

Hans Sachse

Raimund Schuetz

Tor-Einar Svae

Frederic Bal

Petra Schultz

Frank Marks

A process of freeze drying of an essentially aqueous solution comprising at least one first step having a first temperature and pressure level (i.e. primary drying phase) and at least one second step having a second temperature and pressure level (i.e. secondary drying phase) following the first step, wherein in the secondary drying phase limited desorption energy input is applied.

Lyophilisation targeting defined residual moisture by limited desorption energy levels

Process for the stabilization of blood plasma components in a lyophilizate, wherein

Method for stabilizing blood plasma components in a lyophilizate using carbon dioxide and phosphoric acid

A process for preparing a hemostatically active preparation containing von Willebrand factor (vWF) from a fraction of human plasma by chromatographic purification of a vWF-containing plasma fraction on an anion-exchange material which has the anion-exchanging groups on grafted polymeric structures (tentacle materials), collecting a vWF-containing fraction, followed by purification of said fraction using gel permeation to prepare a purified thermally stable vWF-containing preparation; and heating the preparation for inactivating viruses.

Hemostatically active vWF-containing preparation and process for the preparation thereof

Haemostatically active preparation containing vWF and method for the production thereof

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Vienna, Austria

Gerhard Gruber