Novartis Ag

Gerhard Gross

Paul William Manley

Jürg Zimmermann

Peter End

Isabel Ottinger

Daniel Wasmuth

Klaus Olaf Börnsen

Gian P Camenisch

Ulrike Pfaar

Sebastien Bihorel

Michel Lemaire

The present invention provides a method for improving the bioavailability of a renin inhibitor, preferably, of a &#x3b4;-amino-&#x3b3;-hydroxy-&#x3c9;-aryl-alkanoic acid derivative, which method comprises co-administering to a mammal, especially a human, in need of such treatment, a combination of a renin inhibitor, or a pharmaceutically acceptable salt thereof, and an efflux protein inhibitor.

Methods for improving bioavailability of a renin inhibitor

The invention relates to N-phenyl-2-pyrimidine-amine derivatives in which at least one nitrogen atom carries an oxygen atom to form the corresponding N-oxides, to processes for the preparation thereof, to pharmaceutical compositions comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.

N-oxides of N-phenyl-2-pyrimidine-amine derivatives

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Lörrach, Germany

Gerhard Gross