Imago Pharmaceuticals, Inc.

Elan Pharmaceuticals, Inc.

Gergely Toth

Anh Truong

Hing L Sham

Andrei William Konradi

Simeon Bowers

Roy K Hom

R Jeffrey Neitz

Anh P Truong

Gary D Probst

Jennifer Sealy

The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, C, C, Z, R, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

Inhibitors of Jun N-terminal kinase

Growing community of inventors

Palo Alto, CA, United States of America

Gergely Toth