University of Michigan

Gergely Lautner

Mark E Meyerhoff

Steven Paul Schwendeman

Alexander S Yevzlin

Elizabeth J Brisbois

Hang Ren

Orsolya I Lautner-Csorba

Karthik Ramani

Blake Stringer

Griffin Murray

Umadeyi Sajjan

Anant Balijepalli

A method includes mixing a liquid carrier and a powder formulation including an S-nitrosothiol (RSNO) powder to form a nitric oxide generating solution; and within a predetermined time of mixing, introducing the nitric oxide generating solution into an inflatable and nitric oxide permeable balloon of a urinary catheter that is inserted in a patient.

Urinary catheter treatment

Gas delivery devices include different examples of nitric oxide (NO) generating systems. Each example of the NO generating system includes a solid, light sensitive NO donor, and a light source that is operatively positioned to selectively expose the solid, light sensitive NO donor to light in order to generate NO gas.

Gas delivery devices

A polymeric composition includes poly(lactide-co-glycolide) (PLGA) microspheres; and at least one of a discrete RSNO adduct or a polymeric RSNO encapsulated within the microspheres, with the at least one of the discrete RSNO adduct or the polymeric RSNO adduct capable of releasing nitric oxide (NO). The polymeric composition exhibits stability under dry conditions at 37&#xb0; C. and prolonged and controllable NO release rates, when exposed to light capable of photolyzing an RSNO bond, or when exposed to moisture, for a predetermined amount of time from the at least one of the discrete RSNO adduct or the polymeric RSNO adduct.

Nitric oxide releasing PLGA microspheres for biomedical applications

Growing community of inventors

Ann Arbor, MI, United States of America

Gergely Lautner