University of Southern California

Gere Stodder Dizerega

Kathleen Elizabeth Rodgers

Kevin J Gaffney

Described herein are compositions of alginate formulations that include water, divalent ions, and alginate cross-linked by the divalent ions, and their use for treating incisional wounds, such as intra-incisional application.

Use of alginate formulation for intraincisional drug delivery

Angiotensin II Type 2 receptor agonists (AT2 receptor subtype agonists) are useful in accelerating wound healing. These compounds form the basis of compositions useful for accelerating wound healing, in which the active agent is present in an amount effective to accelerate wound healing. Preferably, the compositions are in the form of matrical or micellar solutions.

Use of angiotensin II type 2 receptor agonists in tissue repair

Angiotensin II fragments and analogs thereof are useful in accelerating wound healing. These compounds form the basis of compositions useful for accelerating wound healing, in which the active agent is present in an amount effective to accelerate wound healing. Preferably, the compositions are in the form of matrical or micellar solutions.

Use of angiotensin II fragments and analogs thereof in tissue repair

Compositions and methods for minimizing or preventing post-surgical adhesion formation between tissue, e.g., organ, surfaces in body cavities, whereby an effective therapeutic amount of anti-asthmatic ketotifen (4-1(1-methyl-4-piperidyliden-4H-benzo�4,5!cyclohepta�1,2-b! thiophene-10 (9H)-one, hydrogen fumarate salt) thereof is administered to the target injury site for a period of time sufficient to permit tissue repair. Ketotifen or analogs thereof is preferably administered in conjunction with a delivery vehicle (e.g., microcapsules, microspheres, biodegradable polymer films, lipid-based delivery systems such as liposomes and lipid foams, crystalloid and viscous instillates and absorbable mechanical barriers) useful for maintaining local concentrations of the inhibitor at the injury site at an effective level for a sustained period of time.

Method for reducing or preventing post-surgical adhesion formation using

Use of angiotensin II Type 2 receptor agonists in tissue repair

Hydroxyethyl starch (HES) and use thereof in methods are provided for reducing or preventing of adhesion formation between tissue surfaces, e.g., organ surfaces, in body cavities following surgical procedures and for drug delivery. HES may be used as an absorbable mechanical barrier alone or in combination with one or more anti-adhesion formation compounds for application to injured areas of tissues, e.g., organs, situated in body cavities such as the peritoneal, pelvic, pleural cavity, central nervous system and interligamentous space. HES may also be used as an intracavity carrier device for delivery of pharmaceutically active agents.

Hydroxyethyl starch and use thereof as an absorbable mechanical barrier

Analogs of angiotensin II are useful in accelerating wound healing. These analogs form the basis of compositions useful for accelerating wound healing, in which the active agent is present in an amount effective to accelerate wound healing. Preferably, the compositions are in the form of matrical or micellar solutions.

Use of antiotensin II analogs in tissue repair

Compositions and methods for minimizing or preventing post-surgical adhesion formation between tissue, e.g., organ, surfaces in body cavities, whereby an effective therapeutic amount of manoalide or analog thereof is administered to the target injury site for a period of time sufficient to permit tissue repair. Manoalide or analog thereof is preferably administered in conjunction with a delivery vehicle (e.g., microcapsules, microspheres, biodegradable polymer films, lipid-based delivery systems such as liposomes and lipid foams, crystalloid and viscous instillates and absorbable mechanical barriers) useful for maintaining local concentrations of the inhibitor at the injury site at an effective level for a sustained period of time.

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Pasadena, CA, United States of America

Gere Stodder Dizerega