Basf Aktiengesellschaft

Knoll Aktiengesellschaft

Gerda Von Philipsborn

Dieter Lenke

Wilfried Lubisch

Manfred Raschack

Claus D Mueller

Josef Gries

Albrecht Franke

Fritz Binnig

Fritz-Frieder Frickel

Rainer Schlecker

Walter-Wielant Wiersdorff

Hans-Guenther Hege

Helmut Lietz

Albrecht Franke, Deceased

Liliane Unger

Helmut Hagen

Hardo Siegel

Joerg Rosenberg

Horst Koenig

Wolfgang Spiegler

Sabine Schult

Walter Boell

Bernd Ostersehlt

Josef Mueller

Michael Kirchengast

Hans-Heinrich Gruenhagen

Hans P Albrecht

Juergen Heberger

Egon Brode

Josef Muller

Hans-Gunther Hege

Gerhard Eisen

Beatrice Rendenbach

Hans U Siebeneick

Claus D Muller

p-hydroxy phenone derivatives of the formula I ##STR1## where X is ##STR2## where R.sup.1 =F, Cl, Br or trifluoromethyl or a heteroaryl of the structure ##STR3## with R.sup.2 =C.sub.1 -C.sub.4 -alkyl,

P-hydroxy phenone derivatives used in the treatment of cardiac arrhythmia

Substituted anilides of the formula I ##STR1## (where R.sup.1 is C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, halogen, cyano, nitro, C.sub.2 -C.sub.4 -alkenyl, C.sub.2 -C.sub.4 -alkynyl;

Substituted anilides

A tetracyclic quinazoline derivative of the formula I: ##STR1## wherein A is C.sub.2-3 -alkylene or C.sub.2-3 -alkylene which is substituted by one or two C.sub.1-4 -alkyl radicals or A is cyclohexylene; X is phenyl, naphthyl or phenyl or naphthyl which is substituted by halogen, nitro, amino, C.sub.1-4 -alkylamino, sulfonylamino, C.sub.1-4 -acylamino, hydroxyl, C.sub.1-4 -alkoxy, --O--(CH.sub.2).sub.2-4 --NR.sup.1 R.sup.2, C.sub.1-4 -alkyl or C.sub.1-4 -alkylsulfonyl, wherein R.sup.1 and R.sup.2 are each hydrogen or C.sub.1-4 -alkyl; or X is thienyl or thienyl which is substituted by chlorine, fluorine, methyl, ethyl, methoxy, ethoxy, nitro or hydroxyl; and R is hydrogen, halogen, nitro, amino, C.sub.1-4 -alkylamino, sulfonylamino, C.sub.1-4 -acylamino, hydroxyl, C.sub.1-4 -alkoxy, --O--(CH.sub.2).sub.2-4 --NR.sup.3 R.sup.4, C.sub.1-4 -alkyl or C.sub.1-4 -alkylsulfonyl, wherein R.sup.3 and R.sup.4 are each hydrogen or C.sub.1-4 -alkyl, and the pharmaceutically acceptable salts thereof. The compounds and compositions of the present invention are effective as antiarrhythmic agents.

Tetracyclic quinazoline derivatives, effective as antiarrythmic agents

Aminopropanol derivatives of the formula: ##STR1## where R.sup.1 and R.sup.2 are identical or different and are each hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or hydroxyalkyl, each of not more than 6 carbon atoms, alkoxyalkyl, alkylthioalkyl or dialkylaminoalkyl, each of not more than 9 carbon atoms in total, or phenylalkyl or phenoxyalkyl where the alkyl radical is of not more than 6 carbon atoms and the phenyl radical is unsubstituted or substituted by alkyl or alkoxy, each of not more than 3 carbon atoms, or R.sup.1 and R.sup.2, together with the nitrogen atom which links them, form a 5-membered to 7-membered saturated heterocyclic ring which can be substituted by one or two phenyl and/or hydroxyl radicals and can contain an oxygen or nitrogen atom, as a further heteroatom in the ring, and such an additional nitrogen atom can be substituted by alkyl of 1 to 3 carbon atoms or by phenyl, and -- .circle.Het is thien-2-yl, thien-3-yl, pyrid-2-yl, pyrid-3-yl, pyrid-4-yl, fur-2-yl, 1-alkylpyrr-2-yl, 1-alkylpyrr-3-yl or 1-alkylpyrazol-4-yl, alkyl being of 1 to 3 carbon atoms, and their physiologically tolerated addition salts with acids, and antiarrhythmic agents containing these compounds.

Aminopropanol derivatives of substituted 2-hydroxy-propiophenones, and

p-Hydroxy phenone derivatives of the general formula I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are identical or different and are methyl, chlorine, bromine and hydrogen, but R.sup.1, R.sup.2 and R.sup.3 are not all H,

p-Hydroxy phenone derivatives and the use thereof

P-hydroxy phenone derivatives of the formula 1 ##STR1## where X is ##STR2## where R.sup.1 =F, Cl, Br or trifluoromethyl or a heteroaryl of the structure ##STR3## with R.sup.2 =C.sub.1 -C.sub.4 - alkyl,

P-hydroxy phenone derivatives and drugs containing these

Abstract of the disclosure: p-hydroxy phenone derivatives of the formula I ##STR1## where X is ##STR2## where R.sup.1 =F, Cl, Br or trifluoromethyl or a heteroaryl of the structure ##STR3## with R.sup.2 =C.sub.1 -C.sub.4 -alkyl, Y is a bridging member of the formula --CH.dbd.CH--, --CH.sub.2 CH.sub.2 -- or --CH.sub.2 --,

Bispidine derivatives of the formula I ##STR1## where R, R.sup.1 and R.sup.3 are identical or different and are each H, C.sub.1 -C.sub.4 -alkyl, halogen or C.sub.1 -C.sub.4 -alkoxy, when Y is ##STR2## R.sup.2 is C.sub.1 -C.sub.4 -alkyl, halogen, --CN, C.sub.1 -C.sub.4 -alkoxy, --NHSO.sub.2 CH.sub.3, --CF.sub.3, NH-acetyl or --NR.sup.4 R.sup.5 where R.sup.4 and R.sup.5 are each C.sub.1 -C.sub.4 -alkyl, when Y is ##STR3## R.sup.2 is C.sub.1 -C.sub.4 -alkyl, halogen, --CN.sub.1 C.sub.1 -C.sub.4 -alkoxy, --NHSO.sub.2 CH.sub.3, --CF.sub.3, NH-acetyl or --NR.sup.9 R.sup.10 where R.sup.9 is C.sub.1 -C.sub.4 -alkyl and R.sup.10 is H or C.sub.1 -C.sub.4 -alkyl, and when X is not CH.sub.2 R.sub.2 may also be NO.sub.2 or NH.sub.2, X is --CH.sub.2 --, --C(O)-- or --C(R.sup.6)OR.sup.7 -- (where R.sup.6 is H or C.sub.1 -C.sub.4 -alkyl and R.sup.7 is H, C.sub.1 -C.sub.4 -alkyl or ##STR4## where R.sup.8 is H, C.sub.1 -C.sub.4 -alkyl, halogen or C.sub.1 -C.sub.4 -alkoxy), Y is --C(O) or --CONH-- and Z is C.sub.1 -C.sub.4 -alkylene which may be olefinically unsaturated and/or branched, and their physiologically tolerated salts, and drugs containing these compounds as active compounds are described.

Bispidine derivatives as class III antiarrhythmic agents

Hydroxypropafenone glycerides of the formula I ##STR1## where R is n-propyl or 1,1-dimethylpropyl,

Hydroxypropafenone glycerides

Therapeutic agents containing enantiomers of propafenone, the preparation of the said agents and their use for certain groups of patients.

Therapeutic agents containing enantiomers of propafenone

Pyridine derivatives of the formula ##STR1## where R.sup.1 to R.sup.4 have the meanings stated in the description, and their preparation. The substances are useful for treating disorders.

Compounds 1 or

Novel aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.

Aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones,

Bispidine derivatives of the formula I ##STR1## where R is hydrogen or amino, and their salts with physiologically tolerated acids. The compounds have antiarrhythmic properties.

Bispidine derivatives and antiarrhythmic compositions

Bispidine derivatives of the formula I ##STR1## where R is hydrogen or amino, and their salts with physiologically tolerated acids. The compounds possess antiarrhythmic properties.

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Weinheim, Germany

Gerda Von Philipsborn