Hoffmann-la Roche Inc.

Gerda Huber Trottmann

Roland Jakob-Roetne

Roger David Norcross

Thomas Johannes Woltering

Sabine Kolczewski

Matthias Heinrich Nettekoven

Claus Riemer

Walter Hunkeler

Gavin John Kilpatrick

Amino-triazolopyridine derivatives

The invention is concerned with the use of bi- and tricyclic pyridone compounds of the formula where A, R.sup.1, R.sup.3, R.sup.4, and R.sup.7 are described herein and of their pharmaceutically acceptable salts for the production of medicaments for the prophylaxis or treatment of illnesses which are connected with an inhibition of .beta.-amyloid peptide activity, especially for the treatment of Alzheimer's disease.

Pyridone compounds useful in treating Alzheimer's disease

The invention is concerned with the use of bi- and tricyclic pyridone compounds of the formula ##STR1## where A, R.sup.1, R.sup.3, R.sup.4, and R.sup.7 are described herein and of their pharmaceutically acceptable salts for the production of medicaments for the prophylaxis or treatment of illnesses which are connected with an inhibition of .beta.-amyloid peptide activity, especially for the treatment of Alzheimer's disease.

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Grindel, Switzerland

Gerda Huber Trottmann