Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts

Boehringer Ingelheim International Gmbh

Other

Boehringer Ingelheim Pharma Gmbh & Co Kg

Gerd Stehle

Wolfgang Maier-Borst

Hans-Hermann Schrenk

Hannsj&ouml;rg Sinn

Flavio Solca

Anke Baum

Jacobus C A Van Meel

Andree Amelsberg

Hansj&ouml;rg Sinn

Andreas Wunder

Dieter Ludwig Heene

Dirk Hoff-Biederbeck

Michael Kaus

Michael Klaus

Hansjorg Sinn

Hans-Herman Schrenk

Karlheinz Gross

Heinz H Fiebig

Eva Frei

Jacobus C Van Meel

Jacobus CA Van Meel

The present invention relates to the use of quinazolines of formula (I), wherein the groups Rto Rhave the meanings given in the claims and specification, in cancer therapy.

Quinazoline derivatives for the treatment of cancer diseases

The present invention relates to the use of quinazolines of formula (I), wherein the groups Rto Rhave the meanings given in the claims and specification, in cancer therapy. 

Conjugate consisting of an active substance and a non-exogenous native protein

The invention relates to conjugates comprising a D-enantiomer of a folic acid antagonist and a carrier. Furthermore, the invention relates to the production of such conjugates as well as their use.

Conjugate comprising a folic acid antagonist and a carrier

This invention relates to the use of a conjugate comprising an active substance and a native protein which is not recognized as foreign protein for the production of a pharmaceutical preparation for treating and/or diagnosing inflammatory, infectious and/or skin diseases.

Conjugate for treating inflammatory infectious and/or skin diseases

The present invention relates to a conjugate comprising an active substance and a compound having a binding site for metallic compounds. In addition, this invention relates to a process for the preparation of such a conjugate and its use.

Individual medicament dosing conjugate

The present invention relates to conjugates, comprising an active substance, a polypeptide and a polyether, a process for the production of such conjugates as well as their use.

Conjugate comprising an active agent, a polypeptide and a polyether

The invention relates to a device for detecting input radiation such as X-rays, &ggr;-rays, ionizing radiation or fluorescent and low-level light. The device has at least one detection element comprising a sensor component (scintillator) for converting the input radiation into photons (scintillation light) in the UV, visible or IR part of the electromagnetic spectrum and an optical amplifier component which receives the light converted by the sensor component, forwards it for further processing and amplifies it at the same time. According to the invention, the amplifier component comprises at least one optical waveguide (,) whose material is optically pumped to amplify the scintillation light (,).

Radiation detection device

The present invention relates to conjugates comprising a compound capable of emitting fluorescence, a linker and a protein. The present invention also concerns the preparation of such conjugates as well as their use.

Fluorescent conjugate for differentiating between diseased and healthy tissues

The present invention relates to a process for preparing acid amides by reacting an acid with an aliphatic amine in molten urea. This invention also concerns a process for metalating compounds which can be bonded to a metal ion by reacting the compound with a metal ion in molten urea. Furthermore, the invention deals with the thus obtained products and their use for the therapy and/or diagnosis of tumors or inflammatory diseases.

Preparation of acid amides and metallization of compounds

Conjugate of an active agent, a polyether and possibly a native protein

Method for producing chlorins and bacteriochlorins containing polyether

Conjugate for treating inflammatory diseases

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Ehingen, Germany

Gerd Stehle