A. Nattermann & Cie Gmbh

A. Natternabb & Cie Gmbh

Gerd Hilboll

Gerrit Prop

Hans-Heiner Lautenschlager

Ille-Stephanie Doppelfeld

Harald O Borbe

Josef P Lohr

Jurgen Biedermann

Erich Graf

Hugo Friehe

Sigurd Leyck

Andre Welter

Johannes Winkelmann

Manfred Probst

Brigitte Stoll

Ottfried Zierenberg

Axel Brekle

The invention relates to a new process for the treatment of hypertension and thromboembolic diseases in humans by simultaneous administration of (.+-.)- or (-)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene hydrochloride on the one side, and 4,5-dihydro-6-[4-(1-imidazolyl)-phenyl]-5-methyl-3(2H)-pyridazinone or 4,5-dihydro-6-[4-(1-imidazolyl)-thien-2-yl]-5-methyl-3(2H)-pyridazinone, on the other side, as the active substances.

Process for reducing reflex tachycardia in the treatment of hypertension

The present invention is directed to new, an imidazole group containing 2(1H)-pyridones of formula I ##STR1## salts thereof and process for treating congestive heart failure in humans.

Imidazole group containing 2(1H)-pyridones and method for treating heart

The invention refers to substituted 6-(thien-2-yl)-3(2H)-pyridazinones of Formula I ##STR1##

Substituted 6-(thien-2-yl)-3(2H)-pyridazinones

The invention relates to new imidazolylalkylthienyltetrahydropyridazines of the general formula I ##STR1## their acid addition salts as well as processes for their use in the treatment of cardiovascular and/or thromboembolic illnesses in humans.

Imidazolylalkylthienyl tetrahydropyridazines and processes for their use

The present invention relates to new 6-[Imidazolyl-phenyl]-5-methyl-3-oxo-tetrahydropyridazines of the general formula I ##STR1## as well as their acid addition salts, methods for their use, and pharmaceutical preparations containing them.

Method of treating high blood pressure using

The invention relates to new 6-{4-(.omega.-(1-imidazolyl)-alkyl)-phenyl}-3-oxo-2,3,4,5-tetrahydro-pyrid azines having the general formula I ##STR1## and acid addition salts thereof, and to a process for the treatment of inflammatory, atherosclerotic and thromboembolic diseases especially in humans.

6-{4-(.omega.-(1-imidazolyl)-alkyl-phenyl}-3-oxo-2,3,4,5-tetrahydro-

The invention relates to new 6-{5-[.omega.-(1-imidazolyl)-alkyl]-thien-2-yl}-3-oxo-2,3,4,5-tetrahydro-p yridazines having the general formula I ##STR1## and acid addition salts thereof and to a process for the treatment of inflammatory, atherosclerotic and thrombo-embolic diseases especially in humans.

6-{5-[.omega.-(1-Imidazolyl)-alkyl]

The invention relates to new triphenylimidazolyloxyalkanoic acids of the general formula I ##STR1## and a process for the treatment of thromboembolic, inflammatory and/or atherosclerotic diseases in humans by using the same.

Triphenylimidazolyloxyalkanoic acids and their derivatives and a process

The present invention refers to N-Benzoyl-.omega.-anilinoalkane carboxylic acids, their esters and salts of the general formula ##STR1##

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Cologne, Germany

Gerd Hilboll