Biochemie Gesellschaft M.b.h

Sandoz Gmbh

Nabriva Therapeutics Ag

Biochemie Gmbh

Nabriva Therapeutics Forschungs Gmbh

Sandoz Ag

Gerd Ascher

Johannes Ludescher

Josef Wieser

Hubert Sturm

Johannes Hildebrandt

Heinz Berner

Werner Heilmayer

Michael Schranz

Hellmuth Reinshagen

Rosemarie Mang

Rodger Novak

Werner Veit

Klaus Thirring

Rosemarie Riedl

Herbert Sturm

Heinrich Thaler

Susanne Paukner

Mathias Ferencic

Kurt Riedl

A method of preventing or treating diseases caused bycomprising administering to a subject in need of such treatment an effective amount of a pleuromutilin.

Tuberculosis treatment using pleuromutilin derivatives

14-O&#x2014;[(((C)Alkoxy-(C)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O&#x2014;[(((C)Mono- or dialkylamino-(C)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Hydroxy-(C)-alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Formyl-(C)-alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Guanidino-imino-(C)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Ureido-imino-(C)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Thioureido-imino-(C)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Isothioureido-imino-(C)alkyl)-phenylsulfanyl)-acetyl]-mutilins and their use as pharmaceuticals.

Organic compounds

The present invention relates to Compounds of general formula (I), wherein R is hydrogen and Ris hydroxy or acyloxy, or R is acyl and Ris hydroxy or acyloxy, X is sulphur, oxygen or NR, wherein Ris hydrogen or (C)alkyl; Y is sulphur or oxygen; Ris hydrogen or one or more substituents, e.g. including substituents such as conventional in organic, e.g. (pleuro)mutilin, chemistry; Ris hydrogen or (C)alkyl; Ris hydrogen or (C)alkyl; Rand R' are hydrogen, deuterium, or halogen; R, Rand Rare hydrogen, halogen or deuterium; m is a number selected from 0 to 4, n is a number selected from 0 to 10, and p is a number selected from 0 to 10; with the proviso that n plus p are at least 1. These Compounds are usef&#xfc;l as pharmaceuticals, particularly as antimicrobials. 

Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group

A method of preventing or treating diseases mediated by, comprising administering to a subject in need of such treatment an effective amount of pleuromutilin.

[object Object]

A compound of formula (I) wherein R and Rand the attached nitrogen atom form pyrrolidinyl or piperidinyl. Ris a group of formula (II). Rand R'are hydrogen, deuterium or halogen. R, Rand Rare independently of each other hydrogen or alkyl. R, Rand Rare hydrogen or deuterium. Ris amino, alkyl, aryl, heterocyclyl or mercapto. If X is oxygen, Ris additionally hydrogen; R&#x2032;is alkyl, X is sulphur, oxygen, NR, or N+(R&#x2032;); Y is sulphur or oxygen, and m is 0,1 or 2, with the proviso that, when R and Rand the attached nitrogen atom form piperidinyl, m is O, Y is S and Y is attached in position 3 of the piperidine ring, that group of formula (I) which is attached to the piperidine ring via the residue Y is either in the (S)-configuration or in the (R)-configuration, preferably in the (S)-configuration which is useful as antimicrobial, antibacterial.

Antibacterial mutilins

A compound of formula wherein Ris arylene or heterocyclene; or R and Rtogether with the nitrogen atom to which they are attached form non-aromatic heterocyclene; and the other residues have various meanings, useful as pharmaceuticals, e.g. antimicrobials.

Mutilin derivatives and their use as antibacterials

A compound of formula wherein the substituents have various meanings, useful as a pharmaceutical.

Cephalosporins

A compound of formula wherein Ac, Rand Rhave various meanings, a process for a preparation thereof and its use as a pharmaceutical, i.e. as antibacterial agent.

Antibacterial cephalosporins

A compound of formula (I) wherein R is arylene or heterocyclene; or R and R together with the nitrogen atom to which they are attached form non-aromatic heterocyclene; and the other residues have various meanings, useful as pharmaceuticals, e.g. antimicrobials.

A compound selected from 14&mdash;O&mdash;&lsqb;(cycloalkyl-sulfanyl)acetyl&rsqb;mutilins; 14&mdash;O&mdash;&lsqb;(cycloalkyl-alkyl-sulfanyl)acetyl&rsqb; mutilins; 14&mdash;O&mdash;&lsqb;(cycloalkoxy)acetyl&rsqb; mutilins; and 14&mdash;O&mdash;&lsqb;(cycloalkyl-alkoxy)acetyl&rsqb; mutilins and its use as a pharmaceutical.

Pleuromutilin derivatives having antibacterial activity

Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates

Cephalosporines having cyclic aminoguanidine substituents as antibiotics

Process for the production of 3-vinyl cephalosporins

A process for the production of a 3-vinylcephalosporin compound of formula I

Growing community of inventors

Kundl, Austria

Gerd Ascher