Universiteit Twente

Academisch Ziekenhuis Bij De Universiteit Van Amsterdam

Nederlandse Organisatie Voor Wetenschappelijk Onderzoek

Gerardus Henricus Maria Engbers

Jan Feijen

Jeroen Krijgsveld

Jacob Dankert

Alma Johanna Kuijpers

Sebastianus Antonius Johannes Zaat

The present invention relates to isolated and recombinant antimicrobial peptides thrombocidin-1 (TC-1) and thrombocidin-2 (TC-2), or variants thereof, which comprise at least in part the sequence as shown in FIG.indicated by the label TC-1 and TC-2, and have antimicrobial activity against gram-positive and gram-negative bacteria, for example, and, and/or against fungi, for example, andspec. The invention further relates to the use of said peptides, or variants thereof, for the preparation of a medicament for the treatment of bacterial or fungal infections, such as endocarditis, in humans and animals and the use of said peptides, or variants thereof, in release systems for prevention of bacterial or fungal infections in humans and animals.

Isolated and recombinant antimicrobial peptides thrombocidin-1 (TC-1) and thrombocidin-2(TC-2) or variants thereof

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Oldenzaal, Netherlands

Gerardus Henricus Maria Engbers