Aventis Pharma S.a.

Rhone-poulenc Rorer S.a.

Gerardo Byk

Daniel Scherman

Catherine Dubertret

Bertrand Schwartz

The invention concerns compounds for transferring nucleic acids into cells. The compounds are more particularly related to the lipopolyamine family, and comprise amidine functions. The compounds are useful for transferring nucleic acids of interest into various cellular types, in vitro, in vivo, or ex vivo.

Compounds, preparation and use for transferring nucleic acids into cells

Lipopolyamines useful for the transfection of nucleic acid and methods of preparation thereof are disclosed. The lipopolyamines are of general formula I, in which R4 comprises at least one C10-C22 aliphatic radical.

Lipopolyamines as transfection agents and pharmaceutical uses thereof

Lipopolyamines as transfection agents and pharamaceutical uses thereof

Nucleic acid-containing composition, preparation and use thereof

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Creteil, France

Gerardo Byk