Dublin City University

Royal College of Surgeons in Ireland

Gerardene Meade

Antonio J Ricco

Lourdes Basabe-Desmonts

Luke P Lee

Dermot Kenny

Sofia Ramstrom

Nigel Kent

Bryan Lincoln

Kenny Dermot

Brian Corcoran

Sarah O'Neill

Asif Riaz

The present invention relates to a method, including a diagnostic method, for characterising platelets. More particularly, the invention relates to methods for characterising platelets by immobilising platelets on a substrate for detection and subsequent characterisation, and to devices on which such a method may be practiced. The method comprises the steps of:&#x2014;a. contacting a substrate that includes a plurality of discrete platelet-binding zones having a surface area of 7850 &#x3bc;morless with a fluid composition comprising platelets; and b. detecting platelets bound to the platelet-binding zones and thereby characterising platelets.

Platelet analysis

An object/test material interaction microti iridic device comprising a sample inlet adapted to receive a fluid sample comprising a plurality of objects, an outlet adapted to output the fluid sample from the device, at least one internal surface defining a flow cavity within the device, wherein the flow cavity extends between and is connected to the sample inlet and the outlet for flow of the fluid sample through the flow cavity, the flow cavity comprises a test area to which at least one test material is attached and which is situated in the flow cavity for flow of the fluid sample over the test area, and the flow cavity has an aspect ratio which, when the flow cavity is substantially filled by the fluid sample, provides a substantially constant shear force between the test area and the fluid sample flowing over the test area. The invention further comprises a system incorporating the device, methods of use of the device and system, and methods of analyzing interactions.

Microfluidic device for assessing object/test material interactions

Growing community of inventors

Rush, Ireland

Gerardene Meade