Sanofi

Sanofi-synthelabo

Elf Sanofi

Gerard Valette

Loic Foulon

Georges Garcia

Claudine Serradeil-Le Gal

Claudine Serradeil-Legal

Dino Nisato

Jean Wagnon

Richard Roux

Jean-Marc Herbert

Alain Di Malta

Andre Bernat

Alain Pellet

Bernard Christophe

Danielle Gully

Camille G Wermuth

Pierre M Roger

Daniel Frehel

Gilles Courtemanche

Daniel Mettefeu

Jean-Pierre Bras

Claudine Serradeil-Le-Gal

Loïc Foulon

Laurent Goullieux

Cedric Couturier

Claudie Gautier

Brigitte Pouzet

The present invention relates to novel 3-aminoalkyl-1,3-dihydro-2H-indol-2-one derivatives, to their preparation and to their therapeutic application. The compounds of the present invention correspond to the formula (I): in which the variables are as set forth in the specification. These compounds exhibit a strong affinity and a high selectivity for human arginine-vasopressin (AVP) Vreceptors and some compounds additionally exhibit a strong affinity for AVP Vreceptors.

3-aminoalkyl-1,3-dihydro-2H-indol-2-one derivatives, preparation thereof and therapeutic use thereof

The subject matter of the present invention are compounds corresponding to formula (I):  in which: X is an unsubstituted or substituted divalent (C-C)alkylene radical; Ris an &#x2014;NRRgroup; or an unsubstituted or substituted piperidin-3-yl or piperidin-4-yl radical; Ris a hydrogen atom, a halogen atom, an Alk group or an OAlk group; Ris a hydrogen atom, a halogen atom, an Alk group or an OAlk group; Ris a hydrogen atom, a halogen atom, an Alk group, a hydroxyl or an OAlk group; and Ris a hydrogen atom, a halogen atom, an Alk group, a hydroxyl or an OAlk group.

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Indolin-2-one derivatives, method for preparing them and pharmaceutical

The invention relates to compounds of formula: ##STR1## in which: A is selected from O or S; B is selected from C or N;

Heterocyclic derivatives, process for their preparation and their

The subject of the invention is indolin-2-one derivatives of formula: ##STR1## in which: W represents a --CH.sub.2 -- or --SO.sub.2 -- group;

3-spiro-indolin-2-one derivatives

3-spiro-indolin-2-one derivatives as vasopressin and/or oxytocin

The invention relates to compounds of formula: ##STR1## in which: A is selected from 0 or S; B is selected from C or N; Z.sub.1 is selected from C.sub.1 -C.sub.4 alkylene or phenylene; Z.sub.2 is C.sub.1 -C.sub.4 alkylene; W is NR.sub.1 R.sub.2, in which R.sub.1 is selected from H or C.sub.1 -C.sub.4 alkyl and R.sub.2 is selected from H, C.sub.1 -C.sub.4 alkyl, CONQ.sub.1 Q.sub.2 or CSNQ.sub.1 Q.sub.2 in which Q.sub.1 and Q.sub.2 are independently selected from H or C.sub.1 -C.sub.4 alkyl, SO.sub.2 Q.sub.3 or COQ.sub.3 in which Q.sub.3 is C.sub.1 -C.sub.4 alkyl, COOQ.sub.4 in which Q.sub.4 is selected from C.sub.1 -C.sub.4 alkyl or benzyl, or R.sub.1 and R.sub.2 taken together with N form a saturated heterocycle, or W is selected from C.sub.1 -C.sub.4 alkoxy or thioalkoxy, CONQ.sub.1 Q.sub.2 or CSNQ.sub.1 Q.sub.2, pyridyl, imidazolyl or COOQ.sub.5 in which Q.sub.5 is C.sub.1 -C.sub.5 alkyl; R.sub.3 is not present when B is N, or is H, C.sub.1 -C.sub.8 alkyl or halogen; Ar.sub.1 is selected from optionally substituted phenyl, thienyl, furyl, indolyl, naphthyl or benzyl or Ar.sub.1 and R.sub.3 taken together form a phenylalkylene group; Ar.sub.2 is selected from pyrimidinyl, quinolyl, isoquinolyl, indolyl, isoindolyl or pyridyl, optionally substituted; as well as their salts.

Heterocyclic derivatives process for their preparation and their

The invention relates to 1-Benzenesulfonyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## and their salts, where appropriate, to their preparation and to pharmaceutical compositions in which they are present. These compounds have an affinity for the vasopressin and/or ocytocin receptors.

1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their

1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation

1-benzenesulfonyl-1,3-dihydroindol-2-one derivatives, their preparation

The subject of the invention is the compounds of formula I ##STR1## in which Ar.sub.1 represents naphtyl, phenyl, quinolyl or isoquinolyl optionally substituted;

Compounds bearing sulphamoyl and amidino radicals, their preparation

The present invention relates to 1-benzyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## to their preparation and to the pharmaceutical compositions in which they are present. These derivatives have an affinity for the vasopressin and oxytocin receptors.

1-benzyl-1,3-dihydroindol-2-one derivatives, their preparation and the

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Lacroix Falgarde, France

Gerard Valette