Institut Pasteur

Institut National De La Sante Et De La Recherche Medicale

Other

Roche Molecular Systems, Inc.

Institute Pasteur

Gerard Pehau-Arnaudet

Dina Kremsdorf

Gerard Orth

Michel Favre

Odile Croissant

Sylvie Beaudenon

A purified human papillomavirus gene selected from the group consisting of E1, E6-E7, L1, and L2, wherein said human papillomavirus is selected from the group consisting of HPV-2d, HPV-10b, HPV-14a, HPV-14b, HPV-15, HPV-17a, HPV-17b, HPV-19, HPV-20, HPV-21, HPV-22, HPV-23, HPV-24, HPV-28, HPV-29, HPV-31, HPV-32, HPV-IP2 and HPV-IP4. Polypeptides encoded by these genes. The polypeptides can be used in immunogenic compositions.

Immunogenic compositions of human papillomavirus and sera produced therefrom

The invention concerns human papillomavirus (HPV) DNA and more particularly the probes derived from these papillomaviruses, as well as the methods of detecting HPV using these probes. These human papillomaviruses are designated as HPV-2d, HPV-10b, HPV-14a, HPV-14b, HPV-15, HPV-17a, HPV-17b, HPV-19, HPV-20, HPV-21, HPV-22, HPV-23, HPV-24, HPV-28, HPV-29, HPV-31, HPV-32, HPV-IP2 and HPV-IP4.

Immunogenic compositions of human papillomavirus

The invention relates to papillomavirus probes derived from new DNA-HPVs deposited with the CNCM on the May 6, 1988 under the following filing numbers:

Immunogenic compositions and antibodies directed against human

Papillomavirus probe and a process for in vitro diagnosis of

The invention relates to papillomavirus probes derived from new DNA-HPVs deposited with the CNCM on the 6 May 1988 under the following filing numbers:

Purified polypeptide of human papillomavirus type 49 (HPV49) type 50

The invention relates to human papillomaviruses HPV, particularly to HPV-DNAs isolated from papillomaviruses HPV-2d, HPV-10b, HPV-14a, HPV-14b, HPV-15, HPV-17a, HPV-17b, HPV-19, HPV-20, HPV-21, HPV-22, HPV-23, HPV-24, HPV-28, HPV-29, HPV-31, HPV-32, HPV-IP2 and HPV-IP4. The invention also relates to DNA capable of hybridizing with the HPV-DNAs or fragments thereof, to kits containing distinct groups of probes containing one or more of these HPV-DNAs or fragments thereof, and to procedures for detecting and identifying HPV in tissue.

Papillomavirus probe and process for in vitro diagnosis of

The invention relates to papillomavirus probes derived from new DNA-HPVs deposited with the C.N.C.M. on May 6, 1988, under the following filing numbers:

Isolated DNA of human papillomavirus type 55 (HPV55)

Restriction maps of DNA derived from Human Papillomavirus Types 49, 50, 54, and 55 are disclosed as well as methods for providing recombinant forms of same.

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Montreuil, France

Gerard Pehau-Arnaudet