Johnson & Johnson Consumer Inc.

Mcneil-ppc, Inc.

Merck + Co., Inc.

Gerard P McNally

Harry S Sowden

Vipul Bhupendra Dave

Gregory E Koll

Christopher Szymczak

Oliver Anderson

John J Dubek

Douglas S Beyerle

Joseph R Luber

Der-Yang Lee

David W Wynn

Anurag Pandey

Bruce P Smith

William J Stuhl

Frank J Bunick

Jen-Chi Chen

Edward J Roche

Kishor B Parekh

Dennis C Wieand

Walter G Gowan, Jr

Stephen Ulrich

Thomas J Markley

Douglas R Hough

Kenneth Day

John Case

David B Cochran

Joseph M Morris

Cathy K Gelotte

Frank Hatch

Cynthia Gulian

R Scott Shorts

Glenn Madison

Tom S Ells

Scott H Korn

Christopher E Szymczak

The invention relates to a soft chewable dosage form comprising a first active pharmaceutical ingredient encapsulated in a lipid material that is embedded in the soft chewable dosage form and wherein the soft chewable dosage form comprises at least a second active pharmaceutical ingredient as well as a method of treating a subject suffering from a disease or disorder in the gastro intestinal tract using the soft chewable dosage form.

Soft chewable dosage form

Compositions useful in the treatment of cough and cold symptoms, including but not limited to, cough, nasal congestion and sore throat, are disclosed.

Liquid compositions

A dosage form comprising a tablet core and one or more discontinuous coated regions in various configurations on the surface of the dosage form is disclosed. A method for making the dosage form is also disclosed.

Tablets having discontinuous coated regions

Liquid compositions for treating cough or cold symptoms

The present invention is directed to microencapsulated simethicone particles containing simethicone and a water soluble coating, wherein the simethicone is about 50% by weight of the particle.

Solid simethicone particles and dosage form thereof

The present invention relates to a lozenge dosage form having a disintegrative tablet portion and a candy glass shell portion.

Lozenge dosage form having a disintegrative tablet portion and a candy glass shell portion

In one aspect the present invention features a process for making a tablet comprising the step of applying radiofrequency energy to a powder blend comprising lossy coated particles and at least one pharmaceutically active agent to sinter said powder blend into a tablet, said lossy coated particles comprising a substrate having a Q value of greater than 100 that is at least partially coated with a lossy coating comprising Hydrogenated Starch Hydrolysate.

Process for making tablet using radiofrequency and lossy coated particles

A package including a container and a cover sheet, the container having a first section and a second section connected at a breakable joint, the first section includes a well, and the cover sheet is adhered to at least a portion of the first section and at least a portion of the second section and the cover sheet covers the well. Either the first section or the second section is adapted to pivot to assist in breaking the breakable joint in order to separate the first section and the second section, and allow removal of the cover sheet.

Package with a fulcrum and a lever arm

In one aspect the present invention features process for making a tablet comprising at least one pharmaceutically active agent, said method comprising the step of applying radiofrequency energy to a powder blend to sinter said powder blend into said tablet, wherein said powder blend comprises lossy coated particles and said at least one pharmaceutically active agent, wherein said lossy coated particles comprises a substrate that is at least partially coated with a lossy coating comprising at least one activator, wherein said substrate has a Q value of greater than 100 and said activator has a Q value of less than 75.

A method of administering non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, or acetaminophen is provided. This method provides improved therapeutic effect, in particular pain relief, over extended time periods.

Non-steroidal anti-inflammatory drug dosing regimen

In one aspect, the present invention features a method of manufacturing a solid dosage form, the method including the steps of: (a) measuring an amount of a first powder blend within a dosing nozzle, wherein the first powder blend includes a pharmaceutically active agent; (b) discharging the measured amount of a first powder blend from the dosing nozzle into a forming cavity within a die block, the forming cavity having an inner wall, a first opening at the surface of one side of the die block, and a second opening at the surface on the opposite side of the die block; (c) moving a first forming tool into the forming cavity through the first opening of the forming cavity such that the first powder blend is formed into the shape of the dosage form within the forming cavity between the inner wall, the first forming tool and a second forming tool within or adjacent to the cavity; (d) applying RF energy between a first electrode and a second electrode such that the energy heats the first powder blend within the forming cavity to form the dosage form; and (e) removing the dosage form from the forming cavity.

Method of manufacturing solid dosage form

In one aspect, the present invention features a machine for the production of a solid dosage form wherein the machine is adapted to form a dosage form between a first forming tool and a second forming tool within a forming cavity and wherein the first RF electrode and the second RF electrode are arranged within the machine such that when RF energy is applied between the first RF electrode and the second RF electrode, the RF energy passes through the portion of the forming cavity adapted to form the dosage form.

Machine for production of solid dosage forms

A pharmaceutical composition for oral administration comprising a core and a film coating on the core that exhibits enhanced disintegration characteristics is disclosed. The film coating comprises a film forming polymer, an organic solvent, a super-disintegrant and, optionally, an acid labile material.

Fast dissolving/disintegrating coating compositions

Growing community of inventors

Derwyn, PA, United States of America

Gerard P McNally