Hoffmann-La Roche Inc.

F. Hoffmann-La Roche Ag

Gerard Moine

Jean-Michel Adam

Fabienne Hoffmann-Emery

Patrizio Mattei

Rudolf Schmid

Stefan Hildbrand

Ulrich Zutter

Bruno Lohri

Ursula Hoffmann

Christophe Pfleger

Joseph Foricher

Alec Fettes

Roland Meier

Serena Maria Fantasia

Stefan Abrecht

Pascal Dott

Daniel Vincent Fishlock

Pankaj Rege

Georg Wuitschik

Christian Moessner

Fabian Feyen

The present invention relates to a process for the preparation of 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one derivatives useful as pharmaceutically active compounds.

Process for the preparation of 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo [1,2-B]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one derivatives

The present invention relates to a process for the preparation of 2-pyrazolo[1,5-a]pyrazin-2-ylpyrido[1,2-a]pyrimidin-4-one derivatives useful as pharmaceutically active compounds.

Process for the preparation of 2-pyrazolo[1,5-a]pyrazin-2-ylpyrido[1,2-a]pyrimidin-4-one compounds

This invention relates to a process of the preparation of the novel intermediate (S)-4-fluoromethyl-dihydro-furan-2-one of the formula and with its use for the manufacture of pyrido[2,1-a]isoquinoline derivatives of the formula which are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV.

Process for the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one useful in the preparation of the DPP-IV inhibitor (S)-1 ((2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7, 11b-hexahydro-2H-pyrido[2,1-a] isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one

Growing community of inventors

Basel, Switzerland

Gerard Moine