Aventis Behring Gmbh

Rhone-poulenc Industries

Rhone-poulenc S.a.

Novozymes Biopharma UK Limited

Rhone-poulenc Agrochimie

Novozymes Biopharma Dk A/s

Gérard Jung

Patrice Yeh

Alain Fournier

Reinhard Fleer

Jean-Dominique Guitton

Jacques Mugnier

Jean-Louis Prioul

Yvon Dommergues

Hoang G Diem

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant of human serum albumin, methods for preparation, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing fusion polypeptides.

Methods of treating using hormone-albumin fusion proteins

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

Methods of treatment with interferson and albumin fusion protein

The invention includes biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant of human serum albumin, methods for the preparation of such fusion polypeptides, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing such fusion polypeptides.

Fusion polypeptides of human serum albumin and a therapeutically active polypeptide

Insulin and albumin fusion protein

Interleukin and albumin fusion protein

Hormone and albumin fusion protein

G-CSF and albumin fusion protein

Methods of treatment with erythropoietin and albumin fusion protein

Erythropoietin and albumin fusion protein, nucleic acids, and methods thereof

Interferon and albumin fusion protein

This invention relates to a process of inclusion of microorganisms of the group consisting of mycorrhizae and actinorhizae in a polymer gel matrix to prepare a solid, stable, storable preparation suitable for use in particular for agronomic purposes. The polymer gel matrix is based on at least one polymer from the polysaccharide group, with at least partial cross-linking of the polymer.

Process for inclusion of mycorrhizae and actinorhizae in a matrix

A method of preparing inocula of low water activity is disclosed. The inocula are prepared by admixing microorganisms with a polymer gel and lowering and maintaining the water activity below 0.3, preferably below 0.1. These inocula are useful in the treatment of plant disease, particularly crown gall and Dutch elm diseases, as well as in the biological control of insects.

Low-water-activity inocula for biological control

Inocula having a long storage life and improved resistance to temperature and rehydration and a method of preparing them are disclosed. The method of the invention comprises admixing a culture medium containing microorganisms of the genus Rhizobium and at least one carbohydrate source in a polymer gel and then lowering the water activity of the resulting inoculum and maintaining the water activity at less than 0.1.

Inocula of low water activity with improved resistance to temperature

Provided is a method of obtaining endomycorrhizian fungi with vesicles and arbuscules in vitro. The method comprises producing dicotyledone roots which have been genetically converted by inserting genes of root inducing or tumor inducing plasmid into the genome of dicotyledone roots, and then inoculating the converted roots with endomycorrhiza spores. Application of the present method can be very useful in agriculture and horticulture.

Method of producing endomycorrhizian fungi with arbuscules and vesicles

Novel processes are provided for the embedding of microorganisms within a polymer matrix wherein the matrix comprises a polymer gel having a base of at least one polymer selected from the group of polysaccharides, in which said polymer is at least partially cross-linked. The embedded microorganism products are useful in the inoculation of leguminous and non-leguminous plants in order to increase their nitrogen-fixing potential and nutrition, respectively.

Growing community of inventors

Montlhery, France

Gérard Jung