Stichting Dienst Landbouwkundig Onderzoek

Plant Research International B.v.

Gerard Johan Adolph Rouwendal

Hendrik Jan Bosch

Dionisius Elisabeth Antonius Florack

Hendrikus Antonius Cornelis Bakker

Hendrikus Antonius Cornelus Bakker

Hendrikus Antonius Cornelius Bakker

The present invention relates to non-mammalian &#x3b2;-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian &#x3b2;-1,4-galactosyltransferases and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation. The invention additionally provides nucleic acid molecules and expression vectors of non-mammalian &#x3b2;-1,4-galactosyltransferases.

Mammalian-type glycosylation in plants by expression of a zebrafish glycosyltransferase

The invention is directed to methods for optimizing glycan processing in organisms (and in particular, plants) so that a glycoprotein having complex type bi-antennary glycans and thus containing galactose residues on both arms and which are devoid of (or reduce in) xylose and fucose can be obtained. The invention is further directed to said glycoprotein obtained and host system comprising said protein.

Optimizing glycan processing in plants

The present invention relates to non-mammalian &#x3b2;-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian &#x3b2;-1,4-galactosyltransferase and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation. The invention additionally provides nucleic acid molecules and expression vectors of non-mammalian &#x3b2;-1,4-galactosyltransferases.

Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases

The invention is directed to methods for optimizing glycan processing in organisms (and in particular, plants) so that a glycoprotein having complex type bi-antennary glycans and thus 5 containing galactose residues on both arms and which are devoid of (or reduce in) xylose and fucose can be obtained. The invention is further directed to said glycoprotein obtained and host system comprising said protein.

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Heteren, Netherlands

Gerard Johan Adolph Rouwendal