Delalande S.a.

Other

Gerard H Moinet

Guy R Bourgery

Philippe L Dostert

Alain P Lacour

Bernard M Pourrias

Anne-Marie P Ruch

Michel Langlois

Bernard P Bucher

Jean-Francois R Ancher

Pierre Alfred Bessin

Jacky A Tisne-Versailles

Jacqueline Bonnet

Michel Schaeffer

This invention relates to novel heterocyclic derivatives bearing an amino group and to processes for making said compounds. More particularly this invention provides novel heterocyclic compounds the hetero ring of which has two hetero atoms, the same or different, substituted with a free or substituted amino group. These compounds are useful as active ingredients of drugs.

Novel heterocyclic derivatives bearing an amino radical, processes for

The present invention concerns novel heterocyclic aminoalcoyl derivatives having the formula: ##STR1## wherein n=1, 2 or 3; A represents a nitrogen atom or the CH group, X=CH.sub.2 or CH.sub.2 O; R represents a phenyl nucleus possibly substituted; NR.sub.1 R.sub.2 =amino, methylamino, N,N-dialkylamino or an heterocyclic radical; and R.sub.3 =H, halogen, alkyl, alkyloxy or methoxy. These derivatives are useful as drugs, especially as analgesics and antidepressants.

3-Hydroxyalkyl-3,4-dihydro-1-substituted isoquinolines

The present invention concerns compounds of the formula ##STR1## wherein n=1, 2 or 3; and R' represents phenyl or orthofluorophenyl. Said compounds are used as intermediates in the preparation of heterocyclic aminoalkyl derivatives which are useful as analgesics and antidepressants.

3-(Hydroxyalkyl)-3,4-dihydro-1-orthohalophenyl naphthalenes

Derivatives of formula: ##STR1## in which Z&lt; represents: either an amino group of struture &gt;N-R.sub.1 where R.sub.1 represents a linear or branched alkyl group with 1 to 5 carbon atoms or a phenyl group possibly substituted by a chlorine atom, in which case:

1-Spiro isobenzofuranic and 1-spiro isobenzothiophenic derivatives the

The present invention concerns heterocyclic aminoalcoyl derivatives having the formula: ##STR1## wherein n=1, 2 or 3; A represents a nitrogen atom or the CH group, X=CH.sub.2 or CH.sub.2 O; R represents a phenyl nucleus possibly substituted; NR.sub.1 R.sub.2 =amino, methylamino, N,N-dialkylamino or an heterocyclic radical; and R.sub.3 =H, halogen, alkyl, alkyloxy or methoxy. These derivatives are useful as drugs, especially as analgesics and antidepressants.

Nitrogen containing 2,3-dihydro naphthalenes, compositions and use

1-substituted-4-(3,4,5-trimethoxy) cinnamoyl piperazine compounds are disclosed. The compounds exhibit a substantial activity of stimulating cardiac contractile force, without affecting the cardiac frequency, and they also exhibit coronary vasodilatory and hypotensive effects.

Novel derivatives of 3,4,5-trimethoxy cinnamoyl piperazine, their salts,

Alcohol, thiol, epoxylated alcohol, epoxylated thiol and benzyloxy derivatives of benzodioxane, benzodioxole and benzodioxepine are useful as intermediates for preparing certain useful cinnamoyl piperazines and homopiperazines.

Substituted benzodioxane, benzodioxole and benzodioxepine compounds

Cinnamoyl piperazine and homopiperazine derivatives which possess antiangorous activity and activities on the peripheral and cerebral circulation.

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Orsay, France

Gerard H Moinet