Bristol-myers Squibb Compnay

Gerard Frunzi

Mahesh K Patell

Thomas M Tencza

F Henry Merkle

A tamper-resistant dosage form capsule for the oral administration of therapeutic agents comprises a two-part capsule which is shrunk around a caplet so that the outer wall of the caplet is bound to the inner walls of both parts of the capsule. The caplet is placed into the capsule, and the dosage form is then subjected to relatively high humidity and temperature conditions, followed by drying the dosage form in a lower humidity environment, so that the capsule is shrunk to conform to the contours of the caplet and both parts of the capsule are bonded to the caplet.

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Jamaica Estates, NY, United States of America

Gerard Frunzi