Mediquest Therapeutics, Inc.

Aminex Therapeutics, Inc.

Gerard F Graminski

Mark R Burns

Nand Baindur

Reitha S Weeks

The disclosed invention provides new polyamine analogs and derivatives containing a hydrophobic region and a polyamine region as well as methods and compositions for their use.

Hydrophobic polyamine analogs and methods for their use

Proliferative cutaneous disease states or conditions are treated by administering a polyamine transport inhibitorR-X-L-polyamine

Composition containing polyamine transport inhibitor and use thereof

Novel polyamines, their synthesis and use in pharmacological, cosmetic or agricultural applications are provided. The polyamines induce antizyme production which in turn down regulates both the production of polyamines by omithine decarboxylase (ODC) and the transport of polyamines by its corresponding polyamine transporter. These compounds will preferably enter the cell independent of the polyamine transporter. As drugs, these compounds are used to treat any disease associated with cellular proliferation including but not limited to cancer.

Polyamine analogs that activate antizyme frameshifting

Novel polyamines, their synthesis and use in pharmacological, cosmetic or agricultural applications are provided. The polyamines induce antizyme production which in turn down regulates both the production of polyamines by ornithine decarboxylase (ODC) and the transport of polyamines by its corresponding polyamine transporter. These compounds will preferably enter the cell independent of the polyamine transporter. As drugs, these compounds are used to treat any disease associated with cellular proliferation including but not limited to cancer.

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Shoreline, WA, United States of America

Gerard F Graminski