Societe D'etudes Scientifiques Et Industrielles De L'ile-de-france

Societe D'etudes Scientifiques Et Industrielles De L'ile

Siociete D'etudes Scientifiques Et Industrielles De L'ile-de-france

Gerard C Bulteau

Jacques Acher

Claude H Collignon

Michel Leon Thominet

Jean-Claude Monier

Jean C Monier

Jacques H Archer

Novel substituted 2,3-alkylene bis (oxy) benzamides and derivatives thereof are disclosed. Also disclosed is a method for producing said compounds. The compounds have anxiolytic, psychostimulant, disinhibiting and thymoanaleptic properties useful therapeutically in the psychofunctional field, particularly in gastro-enterology, cardiology, urology, rheumatology and gynaecology.

Substituted 2,3-alkylene di (oxy) benzamides and derivatives

Novel substituted 2,3-alkylene bis (oxy) benzamide azimido compounds and derivatives thereof are disclosed as for example N-(1-allyl-2-pyrrolidylmethyl)-7,8-azimido-1,4-benzodioxane-5-carboxamide and N-(1-allyl-2-pyrrolidylmethyl)-6,7-azimido-1,4-benzodioxane-5-carboxamide. The compounds have anxiolytic, psychostimulant, disinhibiting and thymoanaleptic properties useful therapeutically in the psychofunctional field, particularly in gastro-enterology, cardiology, urology, rheumatology and gynaecology.

Substituted 2,3-alkylene bis (oxy)-4,5 (or 5,6) azimido benzamides and

Substituted 2,3-alkylene bis (oxy) benzamides and derivatives and method

Substituted 2,3-alkylene bis (oxy) benzamides and derivatives

Substituted 2,3-alkylene bis(oxy) benzamides and derivatives to treat

Enamines which are employed to obtain benzamides effective in the treatment of emesis are produced by efficient processes.

Process for producing enamines

Novel substituted N-(1'-ethyl-2'-oxo-5'-pyrrolidinylmethyl) benzamide comnds and derivatives thereof are disclosed. The compounds have psychotropic properties and may be used in pharmaceutical compositions as behavior modifiers.

N-(1'-ethyl-2'-oxo-5'-pyrrolidinylmethyl) benzamide compounds and

The enamines of this invention are useful in the preparation of certain benzamides employed in the treatment of emesis in mammals.

Enamines, their derivatives and processes of production

The azimido benzamide of this invention and its pharmaceutically acceptable salts have an unusually and unexpectedly high therapeutic index and low toxicity in the treatment of emesis in mammals. Pharmacological testing demonstrated the superior efficacy of the compound of this invention over known, similar compounds.

N-(1'-Allypyrrolidinyl 2'-methyl) 2-methoxy 4,5-azimido benzamide and

The benzamides of this invention and their pharmaceutically acceptable salts are particularly effective in the treatment of emesis and ulcers in mammals. Their low level of toxicity is compatible with use in human therapy, without undesirable side effects.

N-(1-benzyl pyrrolidinyl 2-alkyl) substituted benzamides and derivatives

2,5-Disubstituted benzamides are produced by an efficient, effective and economical method by the utilization of 4-methyl 2-chloro 1-3-2-dioxophosphorinane as a catalyst.

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Paris, France

Gerard C Bulteau