Columbia University

University of Missouri

Gerard A Ateshian

Melvin P Rosenwasser

Clark T Hung

Sinisa Vukelic

Robert J Pawluk

Van C Mow

Brian K Jones

James L Cook

Eric G Lima

Li Ming Bian

Brandon Kendrick Zimmerman

Courtney Adair Petersen

A Surgical forceps device comprising a pair of shanks and a clamping jaw portion, the clamping jaw surfaces set at an angle that produces a desired angular position for grasping a bendable osteochondral allograft.

Systems and apparatuses for manipulating bendable allografts

The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage, by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of the tissue being treated. In an embodiment, the femtosecond laser operates in the infrared frequency range.

Laser induced collagen crosslinking in tissue

The present application discloses methods, devices, and systems for generating spatially-resolved quantification of cross-linking in cartilage based on Raman scattering of excitation light. The examples presented demonstrate that the method provides a discriminating power sufficient to distinguish early onset of osteo-arthritis even before a patient is symptomatic.

Devices, methods, and systems for detection of collagen tissue features

A customized allograft that is bendable and suitable for allo-grafting of an articular joint, including the thumb.

Customized bendable osteochondral allografts

Implants for resurfacing or repairing one or more articular cartilage bearing surfaces of a biological organism include an engineered tissue and a biocompatible porous substrate secured to the engineered tissue for attaching the implant to a native bone of the biological organism. The engineered tissue includes a scaffold containing a biocompatible material, and a plurality of living chondrocytes supported by the scaffold. Methods for culturing chondrocytes for incorporation into a biocompatible implant are provided. A bioreactor for producing functional cartilaginous tissue from a cell-seeded scaffold and a system for producing functional cartilaginous tissue are also provided.

Osteochondral implants, arthroplasty methods, devices, and systems

A joint prosthesis for attachment to a bone of a patient, comprising an anchor with a head surface and a stem for attachment to an end of the bone, the head surface having an anatomically accurate shape.

Growing community of inventors

New York, NY, United States of America

Gerard A Ateshian