Hoffmann-La Roche Inc.

F. Hoffmann-La Roche Ag

Gerald Zieres

Bernd Junghans

Bernhard Knipp

Julien Boeuf

Martin Behringer

Bernhard Pfeil

Martin Blum

Vincent Keehnen

Natalie Rakel

Alexander Ulmer

An inventive drug product filling device for filling a liquid drug product into containers is disclosed. The drug filling device includes a drug product preparer configured for preparing the liquid drug product and a filling station configured for filling the liquid drug product into the containers. The filling station is fluidly coupled to the drug product preparer. A degasser is fluidly interposed between the drug product preparer and the filling station. The degasser has a membrane configured for at least partially separating off gas from the liquid drug product. Methods of (i) filling a liquid drug product into containers, (ii) increasing the accuracy of the filling weight of a liquid drug product in a container, (iii) increasing the stability oxygen-sensitive active pharmaceutical ingredient in a liquid drug product, and (iv) reducing polysorbate aggregate formation in a liquid drug product are also disclosed.

Method of filling degassed drug product into containers and drug product filling device

There is provided an improved method for the recovery of residual, unseparated &#x3b2;-acetylfuranoside from reaction mixtures remaining from an initial synthesis of acetylfuranoside, which is in particular usable on a large industrial scale, more particularly in the production of capecitabine.

Process for the recovery of beta acetylfuranoside

A Reactor () for solid phase synthesis comprises a vessel (), a plurality of filters () arranged in the vessel () and a plurality of filtrate outlets () for evacuating the filtrate out of the filters (). Each filter () is connected to one filtrate outlet (). The reactor () comprises means () for delivering a gas into the vessel () in a region of the vessel () near to the bottom () of the vessel () and beside the filters ().

Reactor for solid phase synthesis

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Worms, Germany

Gerald Zieres