Neuromed Technologies, Inc.

Uti Limited Partnership

Neuromed Pharmaceuticals Ltd.

University of Montana

Neuormed Technologies, Inc.

Gerald Werner Zamponi

Terrance P Snutch

Hassan Pajouhesh

Hossein Pajouhesh

Francesco Belardetti

Philippe Diaz

Agustin Garcia-Caballero

Vinicius Gadotti

Norbert Weiss

Terrance Preston Snutch

The present invention provides T-type calcium channel modulators and methods for producing and using the same. In some embodiments, compounds of the invention are of the formula: where

T-type calcium channel modulator and uses thereof

The invention provides methods treating pain by inhibiting a Cav3.2 channel expression or function, including the use of contacting said channel in situ with an inhibitor of USP5 or an inhibitor of the interaction between Cav3.2 and USP5.

Treatment of pain by inhibition of USP5 de-ubiquitinase

Calcium channel blockers

Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.

Preferentially substituted calcium channel blockers

Calcium channel blockers comprising two benzhydril moieties

Calcium channel inhibitors comprising benzhydril spaced from piperazine

Farnesol-related calcium channel blockers

Compounds of the formula ##STR1## wherein m is 0, 1 or 2; wherein when m is 0, Z is O, when m is 1, Z is N, and when m is 2, Z is C;

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Calgary, Canada

Gerald Werner Zamponi