Gem Pharmaceuticals, LLC

Other

Monopar Therapeutics, Inc.

Gerald Walsh

Richard D Olson

Alex F Farris, Iii

Richard Olson

2-pyrrolino-13-deoxyanthracycline derivatives, medical uses thereof, and a process for making them. A 2-pyrrolino-13-deoxyanthracycline and a 13-deoxyanthracycline can be administered to a patient simultaneously or sequentially in amounts to produce a synergistic therapeutic effect with increased potency and efficacy, compared to the sum of the effects of each drug when administered alone. A composition or preparation of a 2-pyrrolino-13-deoxyanthracycline and a 13-deoxyanthracycline for producing a potent anticancer therapeutic effect is also provided.

3'-deamino-3&#x2032;-(2&#x2033;-pyrroline-1&#x2033;-yl)-5-imino-13-deoxyanthracyclines and methods of preparation

A golf club aiming sight device having a clamp portion and a rear sight portion. The rear sight portion has one or more openings to visualize a front sight on a club head of a golf club. The clamp portion provides for the attachment of the golf club aiming sight device to the shaft of the golf club so that the front sight is visually alignable with the opening in the rear sight. The front sight has a triangular shape and the rear sight has a triangular or V shape, thereby allowing rapid and accurate visual alignment of the front and rear sights, even while swinging the golf club. The golf club aiming sight device is used to train a user to swing the golf club without bending or rotating the wrists by having the user maintain the front sight visually aligned with the opening in the rear sight while swinging the golf club.

Golf club aiming sight device

A golf club aiming sight device having a clamp portion and a rear sight portion. The rear sight portion has one or more openings to visualize a front sight on a club head of a golf club. The clamp portion provides for the attachment of the golf club aiming sight device to the shaft of the golf club so that the front sight is visually alignable with the opening in the rear sight. The golf club aiming sight device is used to train a user to swing the golf club without bending or rotating the wrists by having the user maintain the front sight visually aligned with the opening in the rear sight while swinging the golf club.

A 13-deoxy anthracycline and a taxane can be administered to a patient simultaneously, separately, sequentially, or consecutively to produce a therapeutic anticancer effect with reduced toxicity and side effect profile, compared to the administration of equieffective amounts of either compound alone. A composition or preparation of a 13-deoxy anthracyclines and a taxane for producing a potent anticancer therapeutic effect is also provided.

Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines

13-benzenesulfonylhydrazone anthracyclines useful in producing improved yields in the synthesis 13-deoxyanthracyclines, and an improved method of reducing 13-benzene-sulfonylhydrazone anthracyclines to 13-deoxyanthracyclines wherein the reduction reaction is maintained at temperatures of about 55&#xb0; C. to 64&#xb0; C. without stirring or agitation. The reaction is completed with the addition of aqueous bicarbonate which forms the 13-deoxyanthracycline and precipitates. The precipitates are filtered and the precipitate and filtrate are extracted separately with organic solvents. The crude 13-deoxy anthracycline can be converted to 5-imino-13-deoxy anthracycline by reaction with methanolic ammonia. The reaction can also be performed with an acidic pyridinium salt instead of a strong acid so that neutralization of the reaction or extraction of the product is not necessary, thereby facilitating purification.

Compositions and processes for preparing 13-deoxy-anthracyclines

13-benzenesulfonylhydrazone anthracyclines useful in producing improved yields in the synthesis 13-deoxyanthrcyclines, and an improved method of reducing 13-benzene-sulfonylhydrazone anthracyclines to 13-deoxyanthrcyclines wherein the reduction reaction is maintained at temperatures of about 55&#xb0; C. to 64&#xb0; C. without stirring or agitation. The reaction is completed with the addition of aqueous bicarbonate which forms the 13-deoxyanthracycline and precipitates. The precipitates are filtered and the precipitate and filtrate are extracted separately with organic solvents. The crude 13-deoxy anthracycline can be converted to 5-imino-13-deoxy anthracycline by reaction with methanolic ammonia. The reaction can also be performed with an acidic pyridinium salt instead of a strong acid so that neutralization of the reaction or extraction of the product is not necessary, thereby facilitating purification.

Growing community of inventors

Birmingham, AL, United States of America

Gerald Walsh