Glaxo Group Limited

Other

Allen Hanburys Limited

Gerald W Hallworth

David Clough

Paul Kenneth Rand

Michael James

This invention relates to a pharmaceutical composition which is suitable for the administration of medicaments by inhalation. In particular, the pharmaceutical composition comprises microfine particles of medicament and at least one lactose pellet having a diameter of from about 10 to about 1500 micrometers, which pellet comprises a plurality of microfine lactose particles. A method of treating respiratory disorders which comprises administration by inhalation of an effective amount of medicament selected from the group consisting of anti-allergics, bronchodilators, anti-inflammatory steroids and mixtures thereof in the pharmaceutical composition as defined is described also.

Inhalation composition containing lactose pellets

The present invention relates to a pharmaceutical composition which is suitable for the administration of medicaments by inhalation. In particular, the pharmaceutical composition comprises microfine particles of medicament and at least one lactose pellet having a diameter of from about 10 to about 1500 micrometers, which pellet comprises a plurality of microfine lactose particles. A method of treating respiratory disorders which comprises administration by inhalation of an effective amount of medicament selected from the group consisting of anti-allergics, bronchodilators, anti-inflammatory steroids and mixtures thereof in the pharmaceutical composition as defined is also described.

A solid flexible polymeric material is formed by solidifying a water-based latex which contains an inorganic filler. The filler is sand and this may be stabilized in the latex with xanthan gum. The solid material may be a foamed or non-foamed layer which may be used as integral carpet backing, as carpet underlay, or as an adhesive for bonding a reinforcing fabric to the back of carpeting.

Formation of solid polymeric material

A coating material is applied to a surface, such as the back surface of carpeting, using a perforated roller. The material is supplied to the outer surface of the roller so as to form a well of material on the surface passing through the perforated body of the roller up to a second similar roller inside the perforated roller. The roller may be fixed or may be driven depending on the nature of the pattern to be applied to the coating material by the roller.

Coating surfaces

Inhaler container for a medical aerosol

A solid flexible polymeric material is formed by solidifying a water-based latex which contains an inorganic filler. The filler is sand and this may be stabilized in the latex with xanthan gum. The solid material may be a formed or non-foamed layer which may be used as integral carpet backing, as carpet underlay, or as an adhesive for bonding a reinforcing fabric to the back of carpeting.

Formation of solid polymeric material comprising a latex and a filler

A device by which powdered medicaments can be orally or nasally administered to a patient comprises a body shell defining a portion of a chamber. A nozzle or mouthpiece is located at the forward end of the body shell. The body shell is open at the rear end. A sleeve is fitted on the outside of the rear end portion of the body shell and is rotatable and axially movable with respect to it. The sleeve has a rear wall which closes the open rear end of the chamber. A capsule retaining means extends through the rear wall of the sleeve into the chamber. The capsule retaining means has an external entry opening for a capsule at the rear of the sleeve. An abutment is fixed inside the chamber in such a position with respect to the retaining means that a capsule retained in the retaining means and projecting from it into the chamber will engage the abutment when the sleeve is rotated with respect to the body shell. This separates the projecting portion of the capsule from the remainder of the capsule. A grid or guard prevents the separated portion of the capsule from passing through the nozzle or mouthpiece. An air inlet opening extends through the rear wall of the sleeve into the chamber.

Device for dispensing medicaments

An inhaler device for administering medicaments contained in capsules of the kind including a capsule body portion fitted with a capsule cap portion. The device has a body shell provided with an internal chamber. An air inlet opening leads into the chamber. An outlet nozzle through which air can be aspirated leads from the chamber. A capsule receptacle is located inside the chamber, and is arranged so that one of said portions of a capsule can be retained therein. A capsule opening means is positioned in the chamber to engage the other said portion of the capsule retained in the capsule receptacle. The receptacle and the opening means being movable with respect to one another to separate the two said capsule portions from each other.

An inhalation device by which powdered medicaments can be orally or nasally inhaled by a patient through a nozzle. A hollow body shell has a chamber therein. An air inlet leads into the chamber. A capsule retaining means has an inlet opening outside the chamber through which the capsule can be inserted. The retaining means is arranged to retain an inserted capsule with a portion of the capsule body projecting into the chamber as well as to squeeze and deform the overlapping portions of the capsule body and capsule cap. A capsule opening means is located inside the chamber. Said opening means and said retaining means are relatively movable and are so disposed that relative movement between them brings the projecting portion of an inserted capsule and the opening means into engagement with one another so as to separate the capsule body from the capsule cap. A guard prevents the separated capsule body from passing through the nozzle.

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Ware, United Kingdom

Gerald W Hallworth